Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI D3500 2,3-Difluorobenzonitrile is a fluorinated building block that carries a nitrile group together with two adjacent fluorine atoms on the benzene core. The compound belongs to the fluorinated building blocks category, a group of starting materials used specifically to introduce fluorine atoms into the framework of a target molecule. In the laboratory it serves two roles: as a substrate for nucleophilic aromatic substitution reactions, in which one of the fluorine atoms can be displaced by nucleophiles such as amines, alkoxides, or thiolates, and as a source of a nitrile group that can be converted further into amines, amides, carboxylic acids, or tetrazoles.
The principal property behind its selection is the electronic activation provided by the nitrile group. The cyano substituent is a strong electron-withdrawing group, so the ring becomes less electron-rich and the fluorine atom positioned ortho to it is far more readily displaced than fluorine on an ordinary arene. By adjusting temperature, base, and solvent, researchers can direct substitution to one position or the other in a controlled manner. The fluorine atom that remains in the final product delivers the distinctive benefits associated with molecular design, including changes in lipophilicity, changes in the acidity or basicity of nearby groups, and altered stability.
In Indonesian laboratories, this material is typically used in synthetic organic chemistry work where a fluorine-bearing aromatic fragment has to be built into a larger structure. It suits research groups and development laboratories preparing intermediates step by step, where the same starting material supports both the substitution step and the later transformation of the nitrile group. Because a single reagent covers two reaction handles, it fits laboratories that need reliable, well-defined starting materials for multi-step routes rather than one-off preparations.
Laboratory Applications
- Nucleophilic aromatic substitution studies — one fluorine atom is readily displaced by amines, alkoxides, or thiolates, making this a dependable substrate for exploring substitution chemistry on an activated ring.
- Fluorinated intermediate synthesis — the retained fluorine atom stays in the product framework, allowing researchers to build fluorine-bearing aromatic fragments into larger target molecules in a controlled way.
- Nitrile group transformation work — the cyano function can be converted onward into amines, amides, or carboxylic acids, giving laboratories a single reagent with two distinct reaction handles.
- Tetrazole preparation — the nitrile group serves as the direct precursor for tetrazole formation, which is useful when a fluorinated aromatic tetrazole fragment is required in a synthetic route.
- Regioselectivity investigations — because the two fluorine positions differ in reactivity, temperature, base, and solvent can be varied to direct substitution to a chosen position deliberately.
Specifications
- Brand: TCI
- CAS number: 21524-39-0
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: D3500
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering.
- Storage: store according to the conditions stated on the manufacturer's label and safety data sheet.
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from heat, moisture, and incompatible chemicals, following the conditions given on the manufacturer's label and safety data sheet. Keep the material in its original supplier container, or in a clean, chemically compatible and clearly labelled vessel if transferred. Handle in a fume hood using suitable gloves, safety glasses, and a laboratory coat, and avoid inhalation of dust or vapour and contact with skin and eyes. Reseal promptly after weighing to limit moisture uptake, and consult the safety data sheet before use and for waste disposal.
![3'-Bromo[1,1'-biphenyl]-3-carbonitrile (CAS 1040141-34-1) - TCI B5964 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B5964.jpg?v=1769144661&width=533)
![3'-Bromo[1,1'-biphenyl]-4-carbonitrile (CAS 160521-46-0) - TCI B5965 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B5965.jpg?v=1769180247&width=533)
