4-(4,6-Dichloro-2-pyrimidyl)morpholine TCI D4069

Name: TCI D4069 10397-13-4 4-(4,6-Dichloro-2-pyrimidyl)morpholine
Brand: TCI
SKU: TCI2510D406924554
Price: 1505700.0 IDR
Availability: InStock

Rp 1.505.700,00

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Berat 1g

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Description

TCI D4069, 4-(4,6-Dichloro-2-pyrimidyl)morpholine, is a heterocyclic building block that combines a doubly chlorinated pyrimidine ring with a morpholine ring attached at the 2-position. This structure is well known in medicinal chemistry because the pairing of a pyrimidine core with a morpholine group is a motif that appears repeatedly in kinase enzyme inhibitor compounds. In the laboratory, the compound serves as a core scaffold that is ready to be elaborated: the two chlorine atoms provide entry points for nucleophiles, while the morpholine is already installed as a group that contributes solubility character and directs interactions.

The characteristic that makes this material valuable is the difference in reactivity between the two chlorine positions on the pyrimidine ring. That subtle difference allows researchers to carry out nucleophilic aromatic substitution in stages by adjusting temperature, base, and solvent, so that one group can be introduced first before the second. This stepwise approach is highly efficient for building compound libraries with controlled variation at two different positions from a single common starting material. The morpholine ring itself adds polarity and supplies oxygen and nitrogen atoms that can potentially form additional interactions.

In Indonesian laboratories, this building block is typically used in synthetic and medicinal chemistry research groups at universities, government research institutes, and pharmaceutical R&D units working on heterocyclic scaffolds. It suits programmes where a small quantity of a well-defined starting material must support several parallel synthetic routes, and where a reliable branded reagent is preferred so that results can be reproduced across repeated experiments and between different researchers in the same group.

Laboratory Applications

Kinase inhibitor scaffold synthesis: the combined pyrimidine and morpholine motif matches structures repeatedly reported in kinase inhibitor chemistry, making it a direct starting point for such targets.
Sequential nucleophilic aromatic substitution: the two chlorine positions differ in reactivity, so one can be substituted first under controlled conditions before the second is addressed.
Compound library preparation: a single common starting material can be diversified at two distinct positions, giving controlled structural variation without changing the base scaffold.
Medicinal chemistry structure–activity studies: the pre-installed morpholine contributes solubility character and interaction-directing capability while the chlorines allow systematic modification of the remaining positions.
General heterocyclic building block chemistry: the pyrimidine core provides a defined framework for constructing more elaborate heterocyclic systems in multi-step laboratory synthesis.

Specifications

Brand: TCI
CAS number: 10397-13-4
Chemical name: 4-(4,6-Dichloro-2-pyrimidyl)morpholine
Catalogue code: D4069
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in the pack sizes listed by the manufacturer for this catalogue item; storage according to the manufacturer's stated conditions on the label and accompanying documentation

Handling and Storage

Store the container tightly closed in a cool, dry, and well-ventilated place, away from direct sunlight, heat sources, moisture, and incompatible materials, following the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the material in its original container or in a clean, chemically compatible, clearly labelled vessel. Handle in a fume hood using appropriate personal protective equipment, including safety goggles, gloves, and a laboratory coat. Avoid inhalation of dust and contact with skin and eyes. Consult the safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures.