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Description
TCI D4157 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (CAS 64359-81-5) is a heterocyclic compound of the isothiazolinone class, carrying two chlorine atoms on the ring and an n-octyl chain attached to the nitrogen atom. It is widely recognised as an antimicrobial and antifouling active ingredient, and for that reason it is frequently used in the laboratory as a test substance, a working standard, or a formulation component in material preservation research. Its role is important for research activities that evaluate the resistance of materials against fungi, bacteria, and fouling organisms, as well as for the development of analytical methods for biocide residues.
The characteristics that make this compound a preferred choice begin with its broad-spectrum biological activity, which arises from the reactive isothiazolinone ring. This is combined with the octyl chain that gives the molecule a high degree of lipophilicity, so that the compound blends readily into organic matrices such as paints, coatings, and polymers. The two chlorine atoms on the ring further strengthen its reactivity towards thiol groups in biological systems, and this reactivity forms the basis of its mode of action. Its poor solubility in water alongside good solubility in organic solvents means the compound remains relatively persistent within a protective layer — a property that is in fact sought after in durability research.
In Indonesian laboratories, this material is typically handled in coatings and polymer research groups, in material testing units, and in analytical laboratories that develop and validate residue methods. Because it is supplied by TCI as a catalogue building block, it is normally ordered in small quantities for bench-scale preparation of test formulations, for spiking studies, and for reference work rather than for production use. Work with the compound is usually carried out in a fume hood with appropriate personal protective equipment.
Laboratory Applications
- Antimicrobial screening studies — the compound's broad-spectrum activity, arising from the reactive isothiazolinone ring, makes it a suitable positive control or test substance against fungi and bacteria.
- Antifouling research — because it is a recognised antifouling active ingredient, it is used to evaluate how well materials resist attachment by fouling organisms in comparative testing.
- Material preservation and durability testing — its high lipophilicity allows it to be incorporated into paints, coatings, and polymer matrices so that resistance of the finished material can be assessed.
- Biocide residue method development — as a defined isothiazolinone compound with a known CAS number, it serves as a working standard for building and validating analytical residue methods.
- Heterocyclic building block work — its chlorinated isothiazolinone ring, reactive towards thiol groups, makes it a useful starting point for synthetic and mechanistic investigation of this compound class.
Specifications
- Brand: TCI
- CAS number: 64359-81-5
- Chemical name: 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (catalogue code D4157)
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes: available in the standard catalogue pack sizes offered by TCI for this item; please confirm the pack size when ordering
- Storage: store according to the storage conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from heat, direct sunlight, and incompatible materials, and follow the storage conditions printed on the manufacturer's label and safety data sheet. Keep the material in its original TCI container, or in a chemically compatible, clearly labelled and tightly sealed container if it must be transferred. Because the compound is a biologically active antimicrobial agent, handle it in a fume hood and wear appropriate personal protective equipment, including gloves, safety goggles, and a laboratory coat. Avoid contact with skin and eyes, avoid inhaling any dust or vapour, and wash hands thoroughly after handling. Weigh and transfer with dedicated, clean equipment to prevent cross-contamination, and manage residues and empty containers as chemical waste in accordance with your institution's procedures and the safety data sheet.
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