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Description
TCI D4712 3,5-Dihydroxy-4-methylbenzoic Acid, CAS 28026-96-2, is a substituted benzoic acid carrying two hydroxyl groups at positions 3 and 5 together with a methyl group at position 4. It belongs to the class of non-heterocyclic building blocks: aromatic starting materials whose substitution pattern is already established, so they are ready to be elaborated into more complex structures. In organic synthesis laboratories, a molecule presenting three distinct functional groups such as this one carries high value, because each group can be reacted selectively, giving researchers multiple handles for constructing a target molecule in a directed manner.
The property that makes this material a preferred choice is the combination of its functional groups. The carboxylic acid group is readily converted into esters, amides, or acid chlorides; the two phenolic groups can be etherified, acylated, or selectively protected; and the methyl group imparts a distinctive structural signature to the substituted resorcinol framework. The 3,5-dihydroxy pattern also renders the aromatic ring electron-rich, so it tends to undergo electrophilic substitution readily, and this type of skeleton frequently appears as a core unit in polyketide-class natural products.
In Indonesian laboratories, this building block is used mainly in university and institutional research groups working on organic synthesis, medicinal chemistry, and natural product chemistry, as well as in industrial R&D units developing candidate compounds. It is typically drawn on for multi-step synthesis routes, method development work, and the preparation of reference structures, where a well-defined aromatic starting material with several reactive positions shortens the route to the intended target.
Laboratory Applications
- Multi-step organic synthesis — the three different functional groups allow sequential, selective transformations, so a single starting material supports several stages of a planned synthetic route.
- Medicinal chemistry scaffold preparation — the substituted benzoic acid core is readily derivatised into esters and amides, making it useful for building analogue series around a fixed aromatic framework.
- Natural product and polyketide-related research — the 3,5-dihydroxy aromatic skeleton corresponds to core units found in polyketide-class natural products, supporting synthetic and structural investigations.
- Selective protection and deprotection studies — the two phenolic hydroxyl groups plus one carboxylic acid make this compound a practical substrate for developing and comparing protecting-group strategies.
- Electrophilic aromatic substitution work — the electron-rich ring resulting from the 3,5-dihydroxy pattern reacts readily with electrophiles, suiting reactivity studies and further ring functionalisation.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- Product code: D4712
- CAS number: 28026-96-2
- Chemical name: 3,5-Dihydroxy-4-methylbenzoic Acid
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in standard research-scale packaging; physical form, appearance, and lot-specific data should be confirmed against the manufacturer's Certificate of Analysis and Safety Data Sheet supplied with the batch.
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, away from direct sunlight, heat sources, and moisture, and follow the storage condition stated on the product label and Safety Data Sheet for this lot. Keep the material in its original manufacturer packaging where possible; if repackaging is necessary, use clean, chemically compatible, tightly sealing amber glass or suitable plastic containers with clear labelling of name, CAS number, lot, and date opened. Handle in a fume hood using safety glasses, gloves, and a laboratory coat, avoid generating dust when weighing out powder, and close the container promptly to limit exposure to air and humidity. Segregate from strong bases and strong oxidising agents, and dispose of residues and contaminated materials through the laboratory's chemical waste procedure.
