Dolasetron Mesylate Monohydrate TCI D5481

Chemical Identity

Other names: Dolasetron Methanesulfonate Monohydrate
CAS No.: 878143-33-0
PubChem: CID 6918119·SID 468591363
Formula: C19H20N2O3.CH4O3S.H2O
Molecular weight: 438.50 g/mol
Purity: >98.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: methanesulfonic acid;[(3S,7R)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1H-indole-3-carboxylate;hydrate
SMILES: CS(=O)(=O)O.C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54.O
InChIKey: QTFFGPOXNNGTGZ-RCSCTSIBSA-N
MDL: MDL01718979

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Dolasetron Mesylate Monohydrate with CAS number 878143-33-0 is a pharmaceutical research reagent consisting of the hydrated mesylate salt of dolasetron, a serotonin 5-HT3 receptor antagonist. The 5-HT3 receptor is a ligand-gated ion channel distributed across both the central and peripheral nervous systems, where it participates in the signalling pathways that trigger nausea and vomiting. In research settings, this compound serves as a standard reference substance for studying the behaviour of that receptor, validating analytical methods, and supporting experimental pharmacology studies. The product is intended for laboratory and experimental use only, and is not for human administration or clinical practice.

The mesylate monohydrate salt form is selected because sulfonate salts generally offer better aqueous solubility and more practical handling as a solid than the corresponding free base. This makes it easier to prepare aqueous stock solutions for receptor binding assays as well as standard solutions for chromatography. The monohydrate status means that water molecules are bound within the crystal lattice, so molecular mass calculations must be based on the hydrate form in order for prepared solution concentrations to be correct. As a reference compound, clarity of identity and consistency of the material are the properties that matter most to the analyst.

In Indonesian laboratories, this reagent is typically used within university pharmacy and pharmacology departments, government and private research institutes, and analytical laboratories that develop or verify testing methods. It supports method development and system suitability work on chromatographic instrumentation, receptor-level pharmacology investigations, and teaching or training activities at the postgraduate level. In all of these contexts the material functions strictly as an experimental and analytical reference, handled under normal laboratory controls rather than in any clinical or patient-facing capacity.

TCI brochures (PDF)

Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 26

Related TCI products

Receptor binding studies: the compound acts as a defined 5-HT3 receptor antagonist reference, allowing investigators to probe the behaviour of this ligand-gated ion channel under controlled experimental conditions.
Analytical method validation: as a standard reference substance, it supports the establishment and verification of chromatographic and other analytical procedures where a known, consistent comparator is required.
Experimental pharmacology research: the material underpins studies of serotonergic signalling pathways in the central and peripheral nervous systems, including the pathways associated with nausea and vomiting.
Preparation of aqueous standard solutions: the mesylate salt form offers favourable water solubility, making it practical to prepare stock and calibration solutions for laboratory assay work.
Academic teaching and training: the reagent provides postgraduate students and trainees with a well-characterised antagonist for demonstrating receptor pharmacology concepts and reference-standard handling practice.

Brand	TCI
CAS number	878143-33-0
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes	available in standard TCI research packaging; please confirm the currently offered pack size when ordering
Physical form	crystalline solid, supplied as the mesylate monohydrate salt
Storage	follow the conditions stated on the manufacturer's label and accompanying documentation

Catalogue number: D5481

Store the reagent in its original tightly closed container, kept in a cool, dry and well-ventilated area away from direct sunlight, moisture and incompatible materials, following the storage conditions specified on the manufacturer's label. Because the material is a monohydrate, the container should be resealed promptly after weighing to preserve the hydration state and ensure accurate mass calculations. Amber glass or the supplied primary container is appropriate for storage, and prepared solutions should be labelled clearly with concentration and preparation date. Handle the solid in a fume hood or with adequate ventilation, wear a laboratory coat, gloves and safety glasses, avoid generating dust, and wash hands thoroughly after use. Consult the Safety Data Sheet before handling, and dispose of residues and contaminated consumables through the laboratory's chemical waste procedures. The product is for laboratory and experimental use only and must not be administered to humans.

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