TCI D5820 Dolasetron is a selective serotonin 5-HT3 receptor antagonist supplied as a reagent for pharmaceutical research and experimental laboratory use only — it is not intended for administration to humans or animals as a medicine. Within the laboratory it serves as a reference compound and pharmacological tool: researchers use it to probe receptor systems, to validate analytical methods, and to act as a positive comparator in experiments examining the activity of the setron class of compounds. Its availability as a pure, reagent-scale solid allows accurate weighing and the precise preparation of solutions of known concentration.
The characteristics that lead researchers to select this compound are its selectivity as a 5-HT3 receptor antagonist and its well-established position in the pharmacological literature, which makes experimental results easy to compare against existing published work. Its structure, which contains an indole nucleus conjugated with a fused ring system, provides a chromophore that is readily detected by both ultraviolet detectors and mass spectrometers, making the compound convenient to work with in chromatographic applications. As a solid, the material is also easier to store and to dispense accurately than alternatives supplied in other physical forms.
In Indonesian laboratories this reagent is typically found in pharmacology and pharmaceutical research settings — university research groups, pharmacy faculties, and analytical laboratories engaged in method development. It is generally used at small scale for receptor studies, for the preparation of calibration and comparison standards, and as a reference material in chromatographic work. Because it is designated strictly for experimental use, it is handled under the same laboratory controls applied to other research-grade pharmaceutical reagents.
TCI brochures (PDF)
- Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 26
- Receptor system studies: the compound acts as a selective 5-HT3 receptor antagonist, allowing researchers to block this receptor specifically and observe the resulting changes in the biological system under investigation.
- Analytical method validation: as a well-characterised reagent-grade solid, it can be weighed accurately and made up into solutions of known concentration for developing and verifying analytical procedures.
- Positive comparator in setron-class experiments: its established literature record makes it a dependable reference point when evaluating the pharmacological activity of other compounds within the same class.
- Chromatographic work: the conjugated indole nucleus and fused ring system give a chromophore that responds well on ultraviolet detectors, making the compound straightforward to track through separations.
- Mass spectrometry applications: the same structural features that provide ultraviolet response also make the compound readily detectable by mass spectrometer, supporting identification and confirmation work in the laboratory.
| Brand | TCI |
|---|---|
| CAS number | 115956-12-2 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | available in reagent-scale research quantities; please refer to the current TCI catalogue listing for this item |
| Physical form | solid |
| Storage | store according to the conditions stated on the manufacturer's label and product documentation |
Store the material in its original tightly closed container, kept in a cool, dry and well-ventilated place away from direct sunlight and sources of heat or ignition. Glass containers with secure closures are suitable for storage and for the preparation of stock solutions, and containers should be clearly labelled with the compound name, CAS number and preparation date. Handle the solid in a fume hood or a well-ventilated area to avoid generating dust, and wear a laboratory coat, safety glasses and appropriate chemical-resistant gloves. Because this reagent is designated for experimental use only, it must not be used for human or veterinary treatment. Consult the manufacturer's safety data sheet before use, keep it separate from incompatible materials, and dispose of residues and contaminated consumables through the laboratory's established chemical waste procedures.
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Product Categories
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
- Cell BiologyBioactive Small Molecules
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
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