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Description
TCI E0840 Epirubicin Hydrochloride is the hydrochloride salt form of epirubicin, an anthracycline antibiotic that is the 4'-position epimer of doxorubicin. The molecule consists of a conjugated anthracyclinone aglycone core linked to an amino sugar through a glycosidic bond, which makes the compound relevant to the field of glycoscience as well as to oncology-related research. In the laboratory, this material serves as a research reagent and reference compound rather than a therapeutic agent. Researchers use it in studies of anticancer drug mechanisms, cytotoxicity testing on cell cultures, drug delivery system development, and as a standard in analytical method development.
The property that makes this compound important for research is its extensively documented mode of action. Epirubicin intercalates between DNA base pairs and interferes with the activity of topoisomerase II enzymes, thereby inhibiting replication and transcription in rapidly dividing cells. The anthracycline core is also chromophoric and fluorescent, which is a practical advantage because the distribution of the compound inside cells can be observed by fluorescence microscopy without the need for additional labelling. The hydrochloride salt form improves handling characteristics relative to the free base, making the material more convenient to weigh out and prepare for laboratory work.
In Indonesian laboratories, this material is typically encountered in university pharmacology and pharmaceutical chemistry departments, biomedical research institutes, and analytical laboratories that develop and validate methods for anthracycline compounds. It is generally used at small scale in cell culture facilities and instrument rooms, handled under the supervision of trained personnel who follow institutional protocols for cytotoxic research chemicals. Its role in such settings is as a well-characterised reference material against which experimental results can be compared.
Laboratory Applications
Anticancer drug mechanism studies: the documented DNA intercalation and topoisomerase II interference of epirubicin make it a dependable model compound for probing how anthracyclines disrupt replication and transcription.
Cytotoxicity testing on cell cultures: because its cytotoxic behaviour toward rapidly dividing cells is extensively characterised, it serves as a reliable positive control and comparator in cell viability assays.
Drug delivery system development: the hydrochloride salt form eases preparation and loading work, while the fluorescent anthracycline core lets researchers track carrier uptake and release inside cells.
Analytical method development: as a reference compound it supports the establishment, calibration, and comparison of chromatographic and spectroscopic methods intended for anthracycline determination.
Glycoscience research: the amino sugar joined to the aglycone core through a glycosidic bond makes the molecule a useful subject for studying glycosidic linkages in bioactive natural product frameworks.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 56390-09-1
Category: Chemistry > Chemical Biology > Glycoscience
Product code: E0840
Pack sizes: available in laboratory-scale research quantities; please refer to the pack size options listed for this item
Storage note: store according to the manufacturer's stated conditions on the product label and certificate of analysis
Handling and Storage
Store this material in its original tightly closed container, protected from light and moisture, under the storage conditions stated by the manufacturer on the product label. Amber glass or otherwise light-protected containers are appropriate given the chromophoric nature of the anthracycline core. Because this is a cytotoxic research chemical, handle it only in a designated area with appropriate engineering controls, such as a fume hood or biological safety cabinet, and wear gloves, a laboratory coat, and eye protection. Avoid generating dust when weighing the solid, keep the container closed when not in use, and dispose of residues and contaminated consumables through your institution's chemical waste procedures. This product is intended for research use only and not for therapeutic application. Consult the manufacturer's safety data sheet before use.
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