Epalrestat TCI E0906

Name: TCI E0906 82159-09-9 Epalrestat
Brand: TCI
SKU: TCI2510E090628731
Price: 1446900.0 IDR
Availability: InStock

Rp 1.446.900,00

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Berat 1g 5g

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Description

TCI E0906 Epalrestat is a rhodanine-derived compound widely known in the scientific literature as an inhibitor of the enzyme aldose reductase. In this catalogue the material is supplied as a pharmaceutical research reagent intended for laboratory experimental purposes only, not for human use. Its role in the laboratory is that of a test and reference compound in studies of the polyol pathway, the metabolic route that converts glucose into sorbitol and that is considered to contribute to the complications associated with hyperglycaemic conditions. With its documented inhibitory properties, this compound serves as an important tool for researchers tracing the relationship between the activity of that enzyme and biochemical changes observed in experimental models.

The property that makes it a preferred choice is its distinctive chemical structure: a rhodanine core carrying a conjugated system together with a carboxylic acid group, which in combination yield a coloured compound that is readily detected by spectrophotometry. The acid group provides adequate solubility in weakly basic solutions and in polar organic solvents such as dimethyl sulfoxide, so that stock solutions for both enzyme assays and cell-based assays can be prepared without difficulty. This combination of a well-characterised inhibitory profile, convenient optical detectability and straightforward solution handling explains why the compound is repeatedly selected as a benchmark inhibitor rather than a substitute of unknown behaviour.

In Indonesian laboratories the material is typically used in university research groups, pharmacy and medical faculties, and biochemistry or pharmacology research units working on metabolic pathways and enzyme inhibition. It is normally purchased in small research quantities for method development, thesis and dissertation work, and comparative assay studies, where a documented reference inhibitor is required so that results obtained on locally prepared enzyme or cell systems can be interpreted against published experimental findings.

Laboratory Applications

Aldose reductase inhibition assays — the compound is an established inhibitor of this enzyme, so it serves as the positive control that confirms an assay system is responding correctly before unknown samples are measured.
Polyol pathway research — because the pathway converting glucose to sorbitol is the context in which this compound is documented, it allows researchers to interrupt that route deliberately and observe the resulting biochemical changes.
Reference and comparator compound work — its documented inhibitory behaviour makes it a benchmark against which newly synthesised candidate inhibitors can be ranked within the same experimental run and conditions.
Spectrophotometric method development — the conjugated rhodanine system makes the compound coloured and easily detected optically, which suits calibration work, detection-limit studies and routine verification of instrument response.
Cell-based experimental models — adequate solubility in dimethyl sulfoxide and in weakly basic solutions permits preparation of stock solutions that can be diluted into culture systems for enzyme-inhibition studies in experimental models.

Specifications

Brand: TCI
CAS number: 82159-09-9
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes: supplied in research-scale laboratory pack sizes; available options are confirmed at the time of ordering
Physical form: solid organic compound; coloured owing to its conjugated rhodanine structure
Storage: keep in the closed original container under the storage conditions stated on the manufacturer's label

Handling and Storage

Store the container tightly closed in a cool, dry place away from direct sunlight, moisture and sources of heat, following the conditions printed on the manufacturer's label. Keep the material in its original container or in a clean, chemically compatible, well-sealed vessel, and label any prepared stock solution clearly with its solvent, concentration and preparation date. Handle the solid in a well-ventilated area or fume hood using a laboratory coat, gloves and eye protection, and avoid the generation and inhalation of dust. As this reagent is intended for experimental use only and not for human use, it should be handled solely by trained personnel, kept separate from food and beverages, and disposed of together with laboratory chemical waste in accordance with the institution's applicable procedures.