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Description
4-Fluorobenzaldehyde (CAS 459-57-4) is an organic compound belonging to the aromatic aldehyde family, bearing a fluorine atom at the para position relative to the aldehyde group. In the chemistry laboratory, this compound serves as a highly versatile building block and starting material for synthesis, particularly for constructing more complex molecules that contain fluorine. The presence of a reactive aldehyde group allows the compound to undergo a wide range of reactions, including aldol condensation, Grignard reactions, reduction to the corresponding alcohol, and oxidation to the carboxylic acid.
Meanwhile, the fluorine atom imparts unique characteristics to the final products, such as enhanced metabolic stability and increased lipophilicity, which are highly valued in pharmaceutical and materials research. For this reason, 4-Fluorobenzaldehyde is one of the most sought-after starting materials in organic chemistry, medicinal chemistry, and the development of functional materials. The TCI product is recognized for its high purity and consistent quality, making reaction outcomes more reproducible from batch to batch. As a clear to yellowish liquid, the compound is easy to pour and weigh, which simplifies handling on the laboratory bench and reduces the risk of waste during dispensing.
In Indonesian research laboratories, this reagent is commonly used in organic synthesis projects at universities, research institutes, and pharmaceutical development facilities. It serves as a reliable intermediate for preparing fluorinated drug candidates, agrochemical intermediates, and functional organic molecules. Researchers working on heterocyclic synthesis, cross-coupling chemistry, and structure-activity relationship studies frequently select this product because of its dependable purity and stable supply through AMI Scientific. Its liquid form is convenient for accurate dosing in small-scale reactions, which is typical of academic and early-stage industrial research settings.
Laboratory Applications
- Aldol condensation: The reactive aldehyde group readily participates in aldol condensations, enabling the construction of fluorinated α,β-unsaturated carbonyl frameworks that are valuable intermediates in target-oriented synthesis.
- Grignard and organometallic additions: The aldehyde carbonyl acts as an electrophilic acceptor for Grignard and organolithium reagents, giving secondary alcohols bearing both fluorine and a new carbon framework for further elaboration.
- Reduction to fluorinated alcohols: Selective reduction of the aldehyde group produces 4-fluorobenzyl alcohol, a useful building block for ester and ether derivatives applied in medicinal chemistry and material functionalization.
- Oxidation to 4-fluorobenzoic acid: Controlled oxidation converts the aldehyde into 4-fluorobenzoic acid, an important precursor for coordination chemistry, polymer synthesis, and pharmaceutical intermediates.
- Medicinal chemistry scaffold assembly: The fluorine atom improves metabolic stability and lipophilicity of drug candidates, making this aldehyde a preferred starting point for structure-activity relationship studies in drug discovery programs.
Specifications
- Brand: TCI (product code F0191)
- CAS number: 459-57-4
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Physical form: Clear to yellowish liquid
- Pack sizes: Standard laboratory pack sizes available; contact AMI Scientific for current options
- Storage: Store tightly sealed in a cool, dry place away from light and heat
Handling and Storage
Store 4-Fluorobenzaldehyde in its original, tightly sealed container in a cool, dry, and well-ventilated area, protected from direct sunlight and sources of heat. Suitable containers are the original glass or compatible laboratory bottles that resist attack by aldehydes; avoid prolonged contact with plastics that may degrade. When dispensing, work in a fume hood and use personal protective equipment such as chemical-resistant gloves, safety goggles, and a laboratory coat, since aldehydes can irritate the skin, eyes, and respiratory tract. Keep the container closed when not in use to prevent oxidation and moisture uptake, and label all secondary containers clearly.
