TCI F0632 5-Fluoro-o-cresol is a cresol derivative carrying both a methyl group and a fluorine atom on the phenol ring, which is why it is also known as 5-fluoro-2-methylphenol. The compound belongs to the family of fluorinated aromatic building blocks that are widely used as starting materials in multi-step synthesis. In the laboratory, a substituted phenol skeleton of this kind serves as a practical entry point toward aryl ethers, fused heterocyclic compounds, and a broad range of research intermediates, because the three ring substituents already define a reactivity pattern that chemists can work from.
The characteristic that makes this material a preferred choice is the combination of groups with opposing electronic behaviour on a single ring. The hydroxyl and methyl groups are electron-donating and activate the ring, while the fluorine atom withdraws electron density through induction yet is still able to donate density back through resonance. This combination produces a distinctive substitution orientation pattern that is frequently exploited to reach a particular regiochemistry. The phenolic hydroxyl group is also readily deprotonated, leaving it ready for alkylation or acylation, while the methyl group occupies the ortho position relative to it.
In Indonesian laboratories, materials of this type are typically used in academic and industrial research settings where fluorinated intermediates are prepared on a small scale. Because the three substituents on the ring already establish the reactivity pattern, chemists can anticipate the position of subsequent reagent attack in a more directed manner, which makes the compound useful for planning synthetic routes in university organic chemistry groups, research institutes, and applied development laboratories.
TCI brochures (PDF)
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 25
Related TCI products
- Multi-step organic synthesis — the compound functions as a defined starting material whose fixed substitution pattern allows researchers to plan subsequent transformation steps with predictable regiochemical outcomes.
- Aryl ether preparation — the phenolic hydroxyl group is readily deprotonated and then alkylated, making this a direct and convenient entry point toward substituted aryl ether structures.
- Fused heterocycle construction — the activated, substituted phenol ring provides a suitable framework for building condensed heterocyclic systems commonly targeted in exploratory synthetic chemistry programmes.
- Fluorinated intermediate research — as a fluorinated aromatic building block, it supports investigations where the fluorine atom's electronic influence on the aromatic ring is a deliberate design element.
- Regiochemistry and reactivity studies — the opposing electronic effects of the hydroxyl, methyl, and fluorine substituents make it a useful substrate for examining substitution orientation in activated aromatic rings.
| Brand | TCI |
|---|---|
| CAS number | 452-85-7 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | available in standard TCI research-scale packaging; please confirm the available pack options when ordering |
| Physical form | — |
| Storage | keep in the tightly closed original container as indicated on the product label |
- Chemical name: 5-Fluoro-o-cresol (5-fluoro-2-methylphenol)
- Product code: F0632
Store the product in its original tightly closed container, kept in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible reagents. Substituted phenols should be kept in chemically resistant, well-sealed containers to limit exposure to air and moisture. Handle the material inside a fume hood using appropriate personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of vapours and direct contact with skin and eyes. Always consult the manufacturer's safety data sheet before use, and follow institutional procedures for waste collection and disposal.
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