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Description
TCI F0662 2'-Fluoro-4'-methoxyacetophenone is an aromatic ketone carrying an acetyl group on a benzene ring that bears both fluorine and methoxy substituents. The compound belongs to the family of fluorinated building blocks — small starting materials used to construct larger molecular structures in organic synthesis. In the laboratory, an aromatic ketone of this kind is a highly productive point of departure, because its carbonyl carbon can be transformed through a wide range of classical reactions, from condensations and reductions through to the formation of the various heterocyclic frameworks that matter most in modern synthetic chemistry.
The characteristic that makes this material a preferred choice is the combination of three groups whose roles complement one another. The methoxy group is electron-donating and raises the reactivity of the ring at particular positions, while the fluorine atom withdraws electron density inductively, delivering a highly stable carbon–fluorine bond and influencing the polarity and metabolic resistance of the final molecule. The acetyl group supplies a carbonyl carbon that is ready for condensation — for example to form chalcones through an aldol condensation, or to assemble pyridine, pyrazole and isoxazole rings. This defined substitution pattern gives reaction products a predictable orientation.
In Indonesian laboratories, a building block of this type is typically used in organic synthesis research at universities and research institutes, in medicinal chemistry groups exploring fluorinated analogues, and in laboratories preparing heterocyclic intermediates on a small scale. It suits work where the substitution pattern must be fixed from the outset rather than installed later, and it is normally handled in research quantities under standard synthetic laboratory practice.
Laboratory Applications
Chalcone synthesis via aldol condensation — the acetyl carbonyl reacts readily with aromatic aldehydes, and the fixed fluorine and methoxy positions carry through to give a defined substitution pattern in the product.
Heterocyclic ring construction — the methyl ketone moiety serves as a proven precursor for building pyrazole, isoxazole and pyridine rings, giving access to fluorinated heterocyclic scaffolds from a single accessible starting material.
Medicinal chemistry exploration of fluorinated analogues — the stable carbon–fluorine bond influences polarity and metabolic resistance, so this building block lets researchers probe those effects systematically across an analogue series.
Carbonyl reduction and derivatisation studies — the aromatic ketone carbon can be reduced or converted through classical transformations, making the compound a convenient substrate for methodology work and for reaction-condition screening.
Multi-step synthesis of larger molecular targets — as a small fluorinated building block, it supplies an aromatic core whose electronic profile is already established, shortening routes toward more elaborate structures.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 74457-86-6
Chemical name: 2'-Fluoro-4'-methoxyacetophenone
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI research pack sizes; please confirm the currently listed size when ordering
Storage: keep in a tightly closed original container, protected from light, moisture and heat
Handling and Storage
Store the material in its tightly closed original container in a cool, dry and well-ventilated place, away from direct sunlight, heat sources and sources of ignition, and separated from strong oxidising agents. Keep the container closed when not in use to limit exposure to atmospheric moisture. Handle the compound in a fume hood, wearing safety glasses, chemical-resistant gloves and a laboratory coat, and avoid inhalation of dust or vapour and contact with skin and eyes. Weigh and transfer using clean, dry glassware or a spatula, and return the container promptly to its designated storage location. Always consult the manufacturer's Safety Data Sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste regulations.
