Fasudil Hydrochloride TCI F0839

Name: TCI F0839 105628-07-7 Fasudil Hydrochloride
Brand: TCI
SKU: TCI2510F083930828
Price: 5548200.0 IDR
Availability: InStock

Rp 5.548.200,00

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Berat 100mg

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Description

Fasudil Hydrochloride is a pharmaceutical research reagent supplied as the hydrochloride salt of fasudil, an isoquinoline sulfonamide compound known as an inhibitor of Rho-associated protein kinase (ROCK). In the laboratory, this TCI material is used as a molecular tool to temporarily switch off Rho/ROCK signalling so that researchers can observe the downstream consequences for the cytoskeleton, cell shape, cell motility, and cell survival. The product is intended solely for experimental use in the research setting, and not for administration to humans or animals outside approved research protocols.

The property that makes fasudil hydrochloride such a widely chosen form is its salt character, which is far more soluble in water and in buffer solutions than the corresponding free base. This means stock solutions can be prepared without organic solvents that may otherwise disturb cell cultures. Its inhibition of ROCK is reversible and dose-dependent, which makes the compound suitable both for short-duration experiments and for repeated treatment regimes where the investigator needs to apply, withdraw, and reapply the inhibitor across a time course.

In routine cell culture practice, compounds of this class are known to help reduce cell death caused by dissociation from the culture dish, a problem that is particularly familiar in stem cell culture work. Indonesian laboratories working in cell biology, pharmacology, and biomedical research therefore keep this reagent on hand as a standard signalling tool. The 100 mg pack size is appropriate for laboratories preparing stock solutions for ongoing experimental programmes rather than one-off assays.

Laboratory Applications

Rho/ROCK signalling pathway studies, where the reversible and dose-dependent inhibition allows investigators to interrupt the pathway at controlled concentrations and observe the consequences directly.
Cytoskeleton and cell morphology research, since switching off ROCK signalling produces observable changes in cytoskeletal organisation and overall cell shape under the microscope.
Cell migration and motility experiments, because the compound acts as a molecular tool for suppressing the signalling pathway that governs movement in cultured cells.
Stem cell culture work, where compounds of this class are known to help reduce cell death that follows dissociation of cells from the culture dish.
Cell viability and survival assays, as the reagent lets researchers examine how interruption of Rho/ROCK signalling affects whether cultured cells continue to survive.

Specifications

Brand: TCI
CAS number: 105628-07-7
Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack size: 100 mg
Chemical class: isoquinoline sulfonamide, supplied as the hydrochloride salt
Storage: store according to the manufacturer's stated conditions on the product label

Handling and Storage

Store the container according to the conditions stated by the manufacturer on the product label, keeping it tightly closed and protected from moisture, since the hydrochloride salt is prepared for aqueous dissolution and should not be allowed to take up water during storage. Keep the material in its original container or in a clean, well-sealed, chemically compatible vessel that is clearly labelled with the compound name and CAS number. Handle the powder in a suitable ventilated enclosure, wearing a laboratory coat, gloves, and eye protection, and avoid creating dust during weighing. Prepared stock solutions should be aliquoted into labelled tubes to limit repeated handling of the bulk material. As with all research reagents, restrict use to the research area, follow your institutional chemical safety procedures, and dispose of residues and contaminated consumables through the laboratory's chemical waste stream.