Fulvestrant TCI F1144

Chemical Identity

Other names: (7alpha,17beta)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol · ICI 182780
CAS No.: 129453-61-8
Formula: C32H47F5O3S
Molecular weight: 606.78 g/mol
Purity: >98.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
SMILES: CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
InChIKey: VWUXBMIQPBEWFH-WCCTWKNTSA-N
MDL: MDL00903953
PubChem: CID 104741

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Fulvestrant TCI F1144, with CAS number 129453-61-8, is a pharmacological compound widely used in pharmaceutical research, particularly in oncology and endocrinology. As an estrogen receptor antagonist, it plays a critical role in laboratory experiments by inhibiting the activity of estrogen within the body. This compound is essential for studying the effects of estrogen suppression on breast cancer cells, which are among the most common cancer types in Indonesia. Its application in experimental research helps scientists understand the molecular mechanisms of hormone-related diseases and develop targeted therapeutic strategies.

The chemical stability and strong biological activity of Fulvestrant make it a preferred choice for high-precision experiments. Its ability to maintain effectiveness under various laboratory conditions ensures reliable results across different experimental setups. Additionally, its specificity and potency contribute to its widespread use in pharmacological and biochemical studies. These properties make it an indispensable tool for researchers aiming to explore the role of estrogen in disease progression and treatment response.

In Indonesian laboratories, Fulvestrant is commonly used in cancer and endocrine-related research. It is a key component in studies focused on breast cancer, hormonal imbalances, and drug development. Its role in advancing therapeutic approaches for patients with hormone-sensitive cancers underscores its importance in both academic and applied research settings. As a fundamental reagent, it supports the development of more effective and safe treatment options for various health conditions.

Breast Cancer Research – Fulvestrant is used to study the effects of estrogen receptor antagonism on breast cancer cell proliferation, aiding in the development of targeted therapies.
Endocrine Disorder Studies – It helps investigate the role of estrogen in hormonal imbalances, supporting research into conditions like endometriosis and infertility.
Pharmacological Testing – Its strong biological activity makes it ideal for testing the efficacy of new drugs in hormone-related disease models.
Biochemical Assays – Fulvestrant is used in assays that measure receptor binding and signaling pathways, providing insights into cellular responses.
Drug Development Programs – It serves as a key reagent in the screening of potential therapeutic agents for hormone-sensitive cancers and endocrine disorders.

Brand	TCI
CAS number	129453-61-8
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents
Pack sizes	Available in various quantities as per standard laboratory requirements
Physical form	Solid (as per standard product description)
Storage	Store in a cool, dry place away from light and moisture

Fulvestrant should be stored in a cool, dry environment, away from direct sunlight and moisture to maintain its chemical stability. It is recommended to use airtight containers to prevent exposure to air and contaminants. Proper labeling of storage containers is essential to ensure safe handling and prevent cross-contamination. Laboratory personnel should wear appropriate personal protective equipment when handling the compound. Regular monitoring of storage conditions is advised to ensure the integrity of the reagent. Adherence to standard laboratory safety protocols is crucial to maintain a safe working environment.

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