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TCI

CAS 446-72-0

Genistein TCI G0272

Genistein TCI G0272
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Description

Genistein is the most extensively studied naturally occurring isoflavone, largely because of its abundant presence in soybeans and soy-derived products. The compound is built on an isoflavone skeleton carrying several phenolic hydroxyl groups, and these groups determine almost all of its biological behaviour. In research laboratories, genistein serves as a standard test compound for phytoestrogen studies, protein tyrosine kinase inhibition work, antioxidant activity assessment, and a wide range of cellular signalling pathway investigations. Its established status as a reference compound means it appears in nearly every natural-product study connected to soy.

The properties that make genistein a preferred choice for researchers begin with its phenolic structure, which is capable of scavenging free radicals. Equally important is its structural resemblance to estradiol, a similarity that allows the molecule to interact with estrogen receptors and makes it valuable in receptor-binding investigations. Genistein also inhibits certain enzymes at concentrations that can be controlled conveniently under laboratory conditions, giving researchers a workable experimental window. It presents as a crystalline powder with limited solubility in water, so stock solutions are generally prepared in dimethyl sulfoxide or ethanol before dilution into assay media.

In Indonesian laboratories, genistein is typically used in university research groups, natural-product chemistry units, and biochemical laboratories working on soy-related materials. Good reproducibility of results, combined with the availability of an extensive body of published reference literature, makes the data obtained easy to compare against existing work. This makes the compound well suited to teaching laboratories, thesis research, and method development activities where a dependable and widely documented reference isoflavone is required.

Laboratory Applications

  • Phytoestrogen research: genistein's structural similarity to estradiol allows it to interact with estrogen receptors, making it a standard compound for receptor-related investigations.
  • Protein tyrosine kinase inhibition studies: the compound inhibits certain enzymes at concentrations that can be controlled in the laboratory, providing a practical experimental window.
  • Antioxidant activity assays: the multiple phenolic hydroxyl groups on the isoflavone skeleton are able to scavenge free radicals, supporting radical-scavenging test systems.
  • Cellular signalling pathway research: its well-characterised enzyme-inhibiting behaviour makes genistein a widely used probe in signal transduction studies across many cell systems.
  • Soy natural-product reference work: as the most studied isoflavone from soybeans, genistein serves as the reference standard in soy-related natural-product research.

Specifications

  • Brand: TCI
  • CAS Number: 446-72-0
  • Product Code: G0272
  • Category: Life Science > Biochemicals and Reagents > Crude Medicine Ingredients for Research and Experimental Use
  • Physical Form: crystalline powder with limited solubility in water
  • Storage: store according to the conditions stated on the manufacturer's label and product documentation

Handling and Storage

Genistein should be stored in a tightly closed original container, protected from light and moisture, and kept in accordance with the storage conditions stated on the manufacturer's label. Because the material is a crystalline powder with limited water solubility, stock solutions are usually prepared in dimethyl sulfoxide or ethanol before dilution into assay media; prepared solutions should be labelled clearly with the solvent and preparation date. Handle the powder in a well-ventilated area or fume hood to avoid generating dust, and wear standard laboratory personal protective equipment including gloves, safety glasses, and a laboratory coat. Allow sealed containers to reach room temperature before opening to limit moisture condensation, and consult the supplier's safety data sheet before use.

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