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Description
Galantamine Hydrobromide (TCI G0293, CAS 1953-04-4) is the hydrobromide salt of galantamine, an alkaloid of the Amaryllidaceae group that occurs naturally in plants of the amaryllis family such as *Galanthus* and *Narcissus*. In the laboratory, this compound is used as a reagent and reference material in neuropharmacology research, particularly in studies of the cholinergic system, because galantamine is known to act as a reversible acetylcholinesterase inhibitor as well as a positive allosteric modulator at nicotinic acetylcholine receptors. The availability of an alkaloid with a clearly defined chemical identity such as this one forms the basis for developing analytical methods, performing enzyme activity assays, and investigating the mechanism of action of bioactive compounds.
The hydrobromide salt form is chosen because it generally yields a solid that is easier to weigh, handle, and dissolve in aqueous media than the corresponding free base, which makes the preparation of stock solutions for enzymatic assays more practical and more reproducible. Working from a well-behaved salt reduces the handling losses that occur with materials that are difficult to transfer accurately, and it supports consistency between batches of solution prepared on different days or by different analysts. The single CAS number attached to this product also simplifies literature searching, the preparation of safety documentation, and verification of material identity during laboratory audits.
For laboratories in Indonesia, this presentation fits the way alkaloid reference materials are actually consumed in day-to-day research work. The small 100 mg and 1 g pack sizes suit method development, enzyme assay work, and mechanism studies where only limited quantities are required per experiment, so material is not held for long periods before use. A clearly identified reagent supported by a traceable CAS number also helps academic and institutional laboratories meet internal documentation requirements for chemical inventories and research records.
Laboratory Applications
- Cholinergic system research: galantamine acts as a reversible acetylcholinesterase inhibitor, making this defined salt a suitable reagent for studies examining cholinergic signalling in a controlled laboratory setting.
- Acetylcholinesterase enzyme activity assays: the readily soluble hydrobromide salt allows accurate weighing and reproducible stock solution preparation, which is essential for consistent enzyme inhibition measurements across experimental runs.
- Nicotinic acetylcholine receptor studies: galantamine is recognised as a positive allosteric modulator at these receptors, so the compound serves as a reference agent in receptor mechanism investigations.
- Analytical method development: a compound with a clearly defined chemical identity and a single CAS number provides the reliable starting point required when establishing and validating new analytical procedures.
- Mechanism of action studies on bioactive compounds: this well-characterised Amaryllidaceae alkaloid supports investigations into how bioactive natural products exert their biological effects under defined experimental conditions.
Specifications
- Brand: TCI
- CAS number: 1953-04-4
- Category: Life Science > Biochemicals and Reagents > Alkaloids
- Chemical class: Amaryllidaceae alkaloid, hydrobromide salt form
- Pack sizes: 100 mg and 1 g
- Storage: store according to the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container closed in a cool, dry place away from direct sunlight, moisture, and sources of heat, following the storage conditions specified on the manufacturer's label and safety data sheet. Keep the material in its original tightly sealed container, or transfer it to a clean, chemically compatible, well-labelled vessel if subdividing is required. Handle the powder in a fume hood or a well-ventilated area to avoid generating and inhaling dust, and wear a laboratory coat, safety glasses, and suitable gloves. Use clean, dry spatulas when weighing to prevent moisture uptake and cross-contamination. Prepare stock solutions only in the quantities needed, label them clearly with contents and preparation date, and dispose of residues and contaminated materials as chemical waste in accordance with institutional procedures.
