1,1,1,3,3,3-Hexafluoropropan-2-ol is a fluorinated chemical compound widely used in laboratory settings for its unique chemical and physical properties. As a fluorinated building block, it plays a crucial role in organic synthesis and chemical reactions, particularly in the development of organofluorine compounds. This compound is commonly employed as a reagent or catalyst in substitution and oxidation reactions due to its stability and reactivity. Its presence in various research fields, including pharmaceuticals and materials science, highlights its importance in modern chemical experimentation.
The compound’s high solubility in organic solvents and exceptional chemical stability make it a preferred choice for laboratory applications. Its non-polar nature, derived from the strong fluorination, influences its interactions with other molecules, making it suitable for a range of synthetic processes. Additionally, its high boiling point allows it to be used in reactions requiring elevated temperatures without compromising its structural integrity. These properties ensure its reliability and effectiveness in diverse chemical environments.
In Indonesian laboratories, 1,1,1,3,3,3-Hexafluoropropan-2-ol is extensively utilized in organic chemistry research, particularly in the development of new materials and pharmaceutical compounds. Its availability and consistent performance make it a valuable resource for researchers working on fluorinated compounds. The compound’s role in both academic and industrial research underscores its significance in the Indonesian scientific community.
TCI brochures (PDF)
- Organocatalyst for the Synthesis of Chiral Spirolactones 2026-01-06 · p. 1
- Fluorinated Alcohol with Unique Properties HFIP 2025-02-03 · p. 1
- Nucleic Acid Medicine Synthesis Research Reagents 2024-11-07 · p. 1
- Oligonucleotide Synthesis Reagents 2025-07-24 · p. 2
- Reducing Agents 2026-04-06 · p. 3
- Asymmetric Organocatalysts 2025-06-12 · p. 4
Related TCI products
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- TCI T0435 75-89-8 2,2,2-Trifluoroethanol
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- Organic synthesis applications benefit from its reactivity and stability, making it ideal for creating complex fluorinated molecules.
- Pharmaceutical research utilizes this compound in the development of drug compounds due to its unique chemical properties.
- Material science experiments rely on its non-polar nature for creating specialized polymers and coatings.
- Analytical chemistry uses it as a standard for calibration and testing due to its consistent chemical behavior.
- Environmental studies incorporate it in the analysis of fluorinated compounds in various samples.
From the TCI brochure
- Solvent option (CH3OH or HFIP) in the I1122-catalyzed asymmetric lactonization and Diels-Alder scheme
| Brand | TCI |
|---|---|
| CAS number | 920-66-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | Available in various quantities as per supplier specifications |
| Physical form | Liquid |
| Storage | Store in a cool, dry place away from direct sunlight |
Data from the TCI brochure
| Ukuran kemasan | 25g / 100g / 500g |
|---|
Source: TCI brochure RR140 (2026-01-06)
This compound should be stored in a cool, dry environment, away from direct sunlight and sources of heat. It is recommended to use airtight containers made of materials compatible with fluorinated compounds to prevent contamination and degradation. Due to its chemical stability, it does not require refrigeration but should be kept in a secure location to avoid accidental exposure. Laboratory personnel should handle it with appropriate personal protective equipment to ensure safety during use and storage. Proper ventilation is advised when working with this compound to minimize inhalation risks. Regular inspection of storage containers is necessary to maintain the integrity of the compound and ensure safe handling practices are followed.
References cited in the TCI brochure
- Muhammet Uyanik. Hydrogen Bonding and Alcohol Effects in Asymmetric Hypervalent Iodine Catalysis: Enantioselective Oxidative Dearomatization of Phenols Angewandte Chemie International Edition, 2013. doi:10.1002/anie.201303559
- Danièle Bonnet-Delpon. Fluorinated Alcohols: A New Medium for Selective and Clean Reaction Synlett, 2004. doi:10.1055/s-2003-44973
- Andrew J. Phillips. 1,1,1,3,3,3‐Hexafluoro‐2‐propanol Encyclopedia of Reagents for Organic Synthesis, 2021. doi:10.1002/047084289x.rn01164.pub2
- Nelson J. Leonard. 1,1,1,3,3,3-Hexafluoro-2-propanol for the removal of the 4,4′-DimethoxytrityI protecting group from the 5′-hydroxyl of acid-sensitive nucleosides and nucleotides Tetrahedron Letters, 1995. doi:10.1016/0040-4039(95)01673-6
- Alex Apffel. Analysis of Oligonucleotides by HPLC−Electrospray Ionization Mass Spectrometry Analytical Chemistry, 1997. doi:10.1021/ac960916h
- Robert Erb. Comparison of mobile‐phase systems commonly applied in liquid chromatography‐mass spectrometry of nucleic acids ELECTROPHORESIS, 2013. doi:10.1002/elps.201300269
- Michiel C. A. van Vliet. Fluorinated Alcohols: Effective Solvents for Uncatalysed Epoxidations with Aqueous Hydrogen Peroxide Synlett, 2001. doi:10.1055/s-2001-10766
- Albrecht Berkessel. Dramatic Acceleration of Olefin Epoxidation in Fluorinated Alcohols: Activation of Hydrogen Peroxide by Multiple H-Bond Networks Journal of the American Chemical Society, 2006. doi:10.1021/ja0620181
- Akio Saito. Synthesis of 2,3‐Disubstituted Indoles by a Rhodium‐Catalyzed Aromatic Amino‐Claisen Rearrangement of N‐Propargyl Anilines Angewandte Chemie International Edition, 2007. doi:10.1002/anie.200605162
- Misaki Yokota. Activation of 1,1-Difluoro-1-alkenes with a Transition-Metal Complex: Palladium(II)-Catalyzed Friedel–Crafts-Type Cyclization of 4,4-(Difluorohomoallyl)arenes Organic Letters, 2007. doi:10.1021/ol702279w
- Andrew J. Hoteling. Importance of Solubility in the Sample Preparation of Poly(ethylene terephthalate) for MALDI TOFMS Analytical Chemistry, 2005. doi:10.1021/ac048525n
- Nami Hirota. Cooperative α‐helix formation of β‐lactoglobulin and melittin induced by hexafluoroisopropanol Protein Science, 1997. doi:10.1002/pro.5560060218
- Dong-Pyo Hong. Clustering of Fluorine-Substituted Alcohols as a Factor Responsible for Their Marked Effects on Proteins and Peptides Journal of the American Chemical Society, 1999. doi:10.1021/ja990833t
- Lennart Eberson. Making radical cations live longer Chemical Communications, 1996. doi:10.1039/cc9960002105
- Decheng Wan. Xanthate-Mediated Radical Polymerization of N-Vinylpyrrolidone in Fluoroalcohols for Simultaneous Control of Molecular Weight and Tacticity Macromolecules, 2005. doi:10.1021/ma0515230
Product Categories
- Building BlocksFluorinated Building BlocksNon-Heterocyclic Fluorinated Building Blocks
- Chemical BiologyNucleic Acid ChemistryDeprotecting Agents [Nucleic Acid Synthesis]
- SolventsAlcohol Solvents
- Synthetic ReagentsProtection, Deprotection, DerivatizationDeprotecting Reagents [Synthetic Reagents]
- Pharmaceutical Development and Drug Discovery Research ReagentsNucleic Acid ChemistryDeprotecting Agents [Nucleic Acid Synthesis]
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