Levocetirizine Dihydrochloride TCI L0264

Chemical Identity

CAS No.: 130018-87-0
PubChem: CID 9955977·SID 253661576
Formula: C21H27Cl3N2O3
Molecular weight: 461.8 g/mol
Purity: >98.0%(HPLC)(T)
Reference databases: ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride
SMILES: C1CN(CCN1CCOCC(=O)O)[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
InChIKey: PGLIUCLTXOYQMV-GHVWMZMZSA-N

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CoA (Certificate of Analysis)

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TCI L0264 Levocetirizine Dihydrochloride (CAS 130018-87-0) is the dihydrochloride salt of levocetirizine, the active enantiomer of cetirizine. Cetirizine belongs to the second-generation H1 receptor antagonist class of antihistamines. This product is supplied as a pharmaceutical research reagent for experimental use only and is not intended for therapeutic purposes. In the laboratory, levocetirizine dihydrochloride serves as a comparison compound in analytical method development, as a study material for drug chirality research, and as a pharmacological tool for investigating the role of histamine H1 receptors in cells and tissues. It is valuable to researchers who need a material with a clearly defined identity.

Researchers choose this compound mainly because it is a single-enantiomer form. That makes it especially useful in studies that distinguish activity and analytical behaviour between enantiomers, where a racemic mixture would give ambiguous results. The dihydrochloride salt form generally makes it easier to dissolve in aqueous media when preparing stock solutions. Its molecular structure contains aromatic groups, so it can be detected with UV detectors in liquid chromatography. These properties make it a practical choice for routine analytical work as well as exploratory pharmacological studies.

As a TCI product in the pharmaceutical research reagent category, this material supports work that depends on reproducibility, such as method validation and laboratory-scale dissolution testing. In Indonesian laboratories, it is typically used by pharmaceutical quality control and research and development teams, university pharmacy and chemistry departments, and research institutions working on chiral analysis or receptor pharmacology. Teams developing or verifying HPLC methods for antihistamine compounds, and academic groups running cell-based experiments involving histamine signalling, will find it a useful reagent with a well-documented identity.

TCI brochures (PDF)

Immune System, Inflammation, Allergy Research Reagents 2025-05-26 · p. 4
Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 35

Related TCI products

Analytical method development: it serves as a well-identified comparison compound when developing and optimising liquid chromatography methods, and its aromatic structure allows UV detection.
Chiral separation and drug chirality studies: as a single enantiomer of cetirizine, it lets researchers study differences in activity and analytical behaviour between enantiomers.
Method validation work: its defined identity as a TCI research reagent supports repeatable experiments when assessing parameters such as specificity, linearity, and reproducibility of an analytical procedure.
Laboratory-scale dissolution testing: the dihydrochloride salt form generally dissolves readily in aqueous media, which is convenient for preparing solutions used in small-scale dissolution experiments.
Histamine H1 receptor pharmacology: as an H1 receptor antagonist, it acts as a pharmacological tool for studying the role of histamine H1 receptors in cell and tissue models.

Brand	TCI (product code L0264)
CAS number	130018-87-0
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes	see the available options on the product listing or the TCI catalogue
Physical form	refer to the TCI specification sheet and Certificate of Analysis
Storage	follow the storage conditions stated on the product label and Safety Data Sheet (SDS)

Store levocetirizine dihydrochloride in its original, tightly closed container in a cool, dry place away from direct light and moisture, following the conditions stated on the TCI label and Safety Data Sheet. Close the container promptly after each use to limit moisture uptake. Prepare stock solutions in clean, clearly labelled glassware or suitable laboratory vials, and record the preparation date. Wear standard laboratory protective equipment, including gloves, safety glasses, and a lab coat. Avoid creating or inhaling dust, and weigh the material in a well-ventilated area or under local exhaust. This product is for research and experimental use only and is not for human or veterinary therapeutic use. Dispose of waste according to local regulations and institutional procedures.

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