2-Methyl-6-nitrobenzoic Acid with CAS number 13506-76-8 is a substituted benzoic acid supplied by TCI and classified within the non-heterocyclic building blocks group. Its molecular structure carries a methyl group and a nitro group, both occupying ortho positions relative to the carboxylic acid function. This arrangement gives the compound a distinctive character and makes it an important starting material in synthetic chemistry, particularly as a precursor to carboxylic acid activating reagents that are widely recognised among researchers working in total synthesis and macrocyclic chemistry.
The characteristics that make this compound a preferred choice are the combination of steric hindrance and electronic effects. The methyl group on one side provides spatial bulk, while the nitro group on the other side withdraws electron density and increases the electrophilicity of the carbonyl group. The blending of these two influences allows anhydride derivatives of this compound to activate carboxylic acids effectively while simultaneously suppressing unwanted side reactions, so that esterification and lactonisation reactions can proceed under mild conditions. Its solid form facilitates analytical weighing, long-term storage, and repurification by recrystallisation when required.
In Indonesia, this material is used in organic synthesis laboratories at universities and research institutions, as well as in research and development units that prepare complex molecules on a laboratory scale. The solid presentation suits routine handling on an analytical balance, and the compound fits naturally into workflows where a reliable, well-characterised building block is needed as the entry point to a longer synthetic sequence rather than as a finished product.
Related TCI products
- Preparation of carboxylic acid activating reagents, where the ortho methyl and nitro substitution pattern is exactly what gives the resulting anhydride its balance of reactivity and selectivity.
- Esterification of sterically demanding or sensitive substrates, because activation derived from this acid allows the coupling to proceed under mild conditions rather than forcing thermal routes.
- Lactonisation and macrocyclisation studies, where suppression of side reactions is decisive and this building block underpins reagents developed specifically for closing large rings.
- Total synthesis programmes targeting complex natural products, in which a dependable activating precursor is required at multiple stages of a long and demanding reaction sequence.
- General non-heterocyclic building block chemistry, serving as an aromatic scaffold whose methyl and nitro handles can be elaborated further into more advanced synthetic intermediates.
| Brand | TCI |
|---|---|
| CAS number | 13506-76-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in the standard laboratory pack sizes offered for this catalogue item |
| Physical form | solid, suitable for analytical weighing and recrystallisation |
| Storage | keep in a closed container under conditions appropriate for a solid organic acid |
- Product code: M1002
Store the material in a tightly closed original container, kept in a cool, dry and well-ventilated area away from moisture, direct sunlight and sources of ignition. Glass or other chemically compatible containers are appropriate, and containers should be reclosed promptly after each use to limit moisture uptake that could affect weighing accuracy. Handle in a fume hood using standard personal protective equipment, including safety glasses, laboratory gloves and a laboratory coat, and avoid generating dust when weighing the solid. Keep the compound separated from strong bases and strong oxidising agents, label all secondary containers clearly, and follow the manufacturer's safety data sheet together with the institutional chemical waste procedures for disposal of residues.
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