6-Methyl-1-indanone from TCI, supplied under catalogue code M1901, is a bicyclic ketone built on an indanone skeleton — a benzene ring fused to a five-membered cyclopentanone ring, with a methyl group attached at the six position. In organic synthesis laboratories, this compound serves as a non-heterocyclic building block that acts as a starting point for constructing more complex molecules. Its carbonyl group provides a reactive centre for nucleophilic addition, reduction, reductive amination, aldol condensation, and the many other transformations routinely carried out in multi-step synthetic programmes.
The property that makes this material a frequent choice is the combination of a rigid, well-defined indanone framework with carbonyl reactivity that is easy to control. The five-membered ring condensed onto the aromatic core produces a relatively flat and rigid molecular geometry, which is why the scaffold is often used as a core for ligand construction and as a semi-rigid framework in the design of bioactive molecules. The methyl position on the aromatic ring also provides a point of electronic and steric differentiation that is useful when researchers wish to compare the influence of substituents on reaction outcomes.
In Indonesian laboratories, this building block is typically found in university and institutional research groups running organic synthesis and medicinal chemistry programmes, as well as in industrial R&D units developing candidate molecules. It is generally ordered in research quantities for exploratory route development, method optimisation, and the preparation of intermediates that are carried forward into subsequent synthetic steps rather than consumed in routine bulk work.
- Multi-step organic synthesis — the reactive carbonyl centre allows the molecule to be elaborated through successive transformations, making it a practical entry point for building larger target structures.
- Medicinal chemistry scaffold development — the rigid indanone framework serves as a semi-rigid core in the design of bioactive molecules, where defined geometry helps control how substituents are presented.
- Ligand core construction — the flat, well-defined fused-ring geometry makes this compound a useful starting core when researchers assemble ligand structures around a predictable aromatic backbone.
- Substituent effect studies — the methyl group on the aromatic ring provides an electronic and steric reference point for comparing how substitution patterns influence reaction outcomes across a series.
- Carbonyl transformation method work — nucleophilic addition, reduction, reductive amination, and aldol condensation can all be run on this substrate, making it suitable for developing and validating synthetic procedures.
| Brand | TCI, catalogue code M1901 |
|---|---|
| CAS number | 24623-20-9 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in research-scale laboratory pack sizes; please confirm the currently offered options when ordering |
| Physical form | — |
| Storage | keep in the original tightly closed container in a cool, dry, well-ventilated place away from light and ignition sources |
- Compound class: bicyclic ketone, indanone skeleton with a methyl substituent at the six position
Store this material in its original tightly closed container in a cool, dry, well-ventilated area, protected from direct sunlight, heat, and ignition sources, and away from strong oxidising agents. Amber glass or the manufacturer's supplied packaging is suitable for keeping the contents dry and shielded from light. Handle in a fume hood using safety goggles, chemical-resistant gloves, and a laboratory coat, and avoid generating dust or inhaling vapours. Close containers immediately after weighing so that atmospheric moisture is not drawn in, label all secondary containers clearly, and consult the manufacturer's safety data sheet before first use and before disposal of any residues.
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