1-Phenyl-3-pyrazolidone, widely known by the trade name Phenidone, is a five-membered heterocyclic compound. Its ring contains two adjacent nitrogen atoms and one carbonyl group, and a phenyl substituent sits on a nitrogen atom. TCI classifies it as a heterocyclic building block. The compound is best known as a reducing agent in black-and-white photographic developer solutions. In research it is also used as a reference compound in enzyme studies. Its small structure carries several functional groups, so it serves many synthetic purposes in the laboratory.
Chemists choose 1-Phenyl-3-pyrazolidone mainly because it is an effective reducing agent that can donate electrons under relatively mild conditions. In photography it is known to work synergistically with other developing agents such as hydroquinone, which is why it has a long history in developer formulations. In biochemistry, the literature reports it as an inhibitor of the lipoxygenase and cyclooxygenase enzymes. Researchers therefore often use it as a pharmacological tool when studying the arachidonic acid metabolic pathway. The pyrazolidinone ring can also be modified further to produce other heterocyclic derivatives, which makes it useful to synthetic chemists.
In Indonesia, this material is of interest to pharmacology laboratories that study inflammation-related enzyme pathways and need a recognised reference inhibitor for their assays. University and research institute laboratories working in organic synthesis can use it as a heterocyclic starting material for new derivatives. Analytical and imaging laboratories may also use it to study reduction chemistry and developer systems. Because it is supplied under the TCI brand, laboratories can work with a consistent source material in teaching, research, and method development.
- Photographic developer research: as an established reducing agent in black-and-white developers, it suits studies of developer formulations and how it works synergistically with hydroquinone.
- Enzyme inhibition studies: the literature reports it as a lipoxygenase and cyclooxygenase inhibitor, so it is a practical reference compound for enzyme assays and comparison work.
- Arachidonic acid pathway research: pharmacology laboratories use it as a pharmacological tool to look at metabolic routes controlled by lipoxygenase and cyclooxygenase activity.
- Heterocyclic synthesis: its pyrazolidinone ring can be modified further, so it is a useful building block for preparing new heterocyclic derivatives in organic chemistry laboratories.
- Reduction chemistry studies: it donates electrons under relatively mild conditions, so it suits teaching and research experiments that look at reducing behaviour and electron-transfer reactions.
| Brand | TCI (product code P0153) |
|---|---|
| CAS number | 92-43-3 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | please check the product listing for the pack sizes currently offered |
| Physical form | solid; see the supplier's certificate of analysis for full details |
| Storage | keep the container tightly closed in a cool, dry place, following the TCI label and safety data sheet |
Store 1-Phenyl-3-pyrazolidone in its original, tightly sealed container in a cool, dry, well-ventilated area, away from direct light and heat. Because it is a reducing agent, keep it separate from strong oxidising agents. Use clean, dry spatulas and close the container right after use so the material is not exposed to moisture and air for long. When handling it, wear standard laboratory protective equipment, including gloves, safety glasses, and a lab coat. Do not create or breathe in dust; weighing in a fume hood or ventilated enclosure is recommended. Always read the TCI safety data sheet before use, and dispose of waste according to local laboratory and environmental rules.
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