Phosphorus Pentoxide - Methanesulfonic Acid TCI P1042

Chemical Identity

CAS No.: 39394-84-8
PubChem: CID 16149098·SID 87575154
Formula: CH4O8P2S
Molecular weight: 238.05 g/mol
Reference databases: ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

SMILES: CS(=O)(=O)O.O=P(=O)OP(=O)=O
InChIKey: JHNLZOVBAQWGQU-UHFFFAOYSA-N

Rp 1.326.150,00

Sale Sold out

Shipping calculated at checkout.

Berat 25g 500g

Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 2-4 minggu setelah pembayaran.

Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

CoA (Certificate of Analysis)

Spesifik per batch produksi — diterbitkan dan dikirim bersama barang sesuai nomor lot yang Anda terima.

Contoh CoA segera tersedia.

💬 Minta CoA via WhatsApp

View full details

Phosphorus Pentoxide - Methanesulfonic Acid (TCI P1042, CAS 39394-84-8) is a solution of phosphorus pentoxide in methanesulfonic acid. Organic chemists usually call it Eaton's reagent. It is a strongly acidic medium and a dehydrating agent at the same time, so it is used to drive condensation, cyclization and acylation reactions. Many laboratories use it in place of polyphosphoric acid (PPA) for reactions that need strongly acidic conditions and the removal of water. Its role at the bench is to promote ring-forming and bond-forming steps that will not proceed well under milder acid catalysis.

The main advantage of Eaton's reagent over PPA is its much lower viscosity. Because it is more fluid, it is easier to stir, transfer and mix with substrates, which gives more even reaction conditions and handling that is easier to reproduce. Work-up after the reaction is also simpler, and reactions can often run at lower temperatures than with PPA. Methanesulfonic acid supplies strong acidity and phosphorus pentoxide supplies dehydrating power. Together they make the reagent effective for intramolecular Friedel–Crafts acylation, cyclic ketone synthesis, and the formation of heterocycles such as quinolones, benzimidazoles and benzoxazoles.

In Indonesia, this reagent is useful for organic synthesis, medicinal chemistry and materials chemistry laboratories that regularly prepare polycyclic or heterocyclic compounds. University research groups building heterocyclic scaffolds, pharmaceutical development teams preparing intermediates, and materials laboratories making fused aromatic systems can all use it as a more practical alternative to PPA. It is supplied under the TCI brand in the Dehydrating Reagents category, so researchers get a ready-made reagent and do not need to prepare the mixture themselves.

Related TCI products

Intramolecular Friedel–Crafts acylation: the strong acidity and dehydrating power of the reagent promote ring closure onto aromatic systems, and its low viscosity makes stirring and work-up easier than with PPA.
Synthesis of cyclic ketones: the reagent drives cyclization of suitable acid precursors by removing water, often at lower reaction temperatures than more viscous polyphosphoric acid systems need.
Formation of quinolone heterocycles: combining an acidic medium with a dehydrating agent supports the condensation and cyclization steps needed to build quinolone ring systems in medicinal chemistry work.
Preparation of benzimidazoles and benzoxazoles: the reagent helps condensation reactions that form these heterocyclic cores by pulling water out of the system, which drives the reaction toward ring closure.
Replacing PPA in condensation reactions: laboratories switching from PPA get a fluid reagent that is easier to transfer, mix and quench, so processes are simpler to reproduce and scale.

Brand	TCI (product code P1042)
CAS number	39394-84-8
Molecular formula	—
Purity	—
Category	Chemistry > Synthetic Reagents > Dehydrating Reagents [Synthetic Reagents]
Pack sizes	as listed on the product page
Physical form	solution of phosphorus pentoxide in methanesulfonic acid (Eaton's reagent)
Storage	keep tightly closed in a dry place, protected from moisture; follow the manufacturer's label and safety data sheet

Phosphorus Pentoxide - Methanesulfonic Acid is a strongly acidic, corrosive and moisture-sensitive reagent. Keep it in its original tightly sealed, acid-resistant container in a cool, dry, well-ventilated area, away from water, bases, oxidizers and other incompatible materials. Reseal the container promptly after use so it does not absorb atmospheric moisture. Handle it only in a fume hood while wearing chemical-resistant gloves, safety goggles or a face shield, and a lab coat. Quench reaction mixtures carefully, because contact with water can generate heat. Always read the manufacturer's safety data sheet before use and dispose of waste according to local regulations.

—