Posaconazole TCI P2477

Posaconazole from TCI is a newer-generation triazole antifungal compound supplied as a research reagent for laboratory use. It works by inhibiting the fungal enzyme lanosterol 14α-demethylase (CYP51). This enzyme is a key step in the biosynthesis of ergosterol, an essential component of the fungal cell membrane. TCI lists posaconazole in its antibiotics category. Laboratories use it in microbiology and pharmacology studies, and as a reference standard when developing new antifungal agents. This product is intended for research use only.

Posaconazole is known for its broad spectrum of antifungal activity. This spectrum covers a wide range of yeasts and moulds, including several fungi that respond poorly to older triazoles. The molecule is large and carries a long side chain, which makes it useful for studying interactions with the CYP51 active site and for antifungal resistance research. Its pharmacological profile is well documented in published literature. For this reason, posaconazole is often used as a positive control in antifungal susceptibility testing. It is also used as a reference compound in drug metabolism studies involving cytochrome P450 enzymes.

In Indonesia, fungal infections remain a significant concern, and posaconazole supports research work in university microbiology departments, pharmaceutical research and development units, and biomedical research institutes. Researchers use it to compare the activity of new antifungal candidates, to characterise clinical or environmental fungal isolates, and to investigate resistance mechanisms in local strains. AMI Scientific supplies the genuine TCI product so that Indonesian laboratories have a dependable, well-characterised reference compound for this work.

• Antifungal susceptibility testing: posaconazole is commonly used as a positive control because its broad spectrum and well-documented activity give laboratories a dependable benchmark for each assay run.
• CYP51 enzyme inhibition studies: posaconazole inhibits lanosterol 14α-demethylase, and its large structure with a long side chain makes it a useful probe of interactions at the enzyme's active site.
• Antifungal resistance research: posaconazole is active against some fungi that respond poorly to older triazoles, which makes it valuable for comparing resistance patterns and studying the underlying mechanisms in fungal isolates.
• Development of new antifungal agents: posaconazole's established pharmacological profile makes it a suitable reference standard for judging the potency and spectrum of new antifungal candidates in screening programmes.
• Drug metabolism research: posaconazole is widely studied for its interaction with cytochrome P450 enzymes, so it serves as a reference compound in metabolism and drug-interaction studies.

Store posaconazole in its original, tightly closed container in a cool, dry place away from direct light and moisture, unless the TCI label specifies other conditions. Keep the container sealed between uses to protect the material from humidity and contamination. Handle the compound in a well-ventilated area or a fume hood. Wear appropriate personal protective equipment, including gloves, a laboratory coat, and safety glasses. Avoid inhaling dust and avoid contact with skin and eyes. Read the Safety Data Sheet before use, and dispose of residues and contaminated materials according to your institution's chemical waste procedures. This product is for research use only and is not intended for diagnostic or therapeutic use.

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