2-Phenylpyrrolidine from TCI is a heterocyclic secondary amine. It consists of a saturated five-membered pyrrolidine ring with a phenyl substituent on the carbon atom next to the nitrogen. In the laboratory it serves as a valuable heterocyclic building block for medicinal chemistry and organic synthesis. Many bioactive molecules and drug candidates contain a 2-arylpyrrolidine scaffold. For this reason the compound is often the starting point for building compound libraries, ligands, or intermediates in multistep synthetic routes.
Chemists choose this compound because it combines several useful properties. Its secondary nitrogen is reasonably nucleophilic and basic, so it is easy to derivatize by alkylation, acylation, sulfonylation, reductive amination, or C–N coupling reactions. The carbon atom that carries the phenyl group is a stereogenic centre. This makes the compound relevant to studies of enantiomer resolution, chiral chromatographic analysis, and the development of pyrrolidine-based organocatalysts. The phenyl group adds lipophilicity and allows aromatic interactions, which are often important when a molecule binds to a biological target.
In Indonesia, 2-Phenylpyrrolidine is useful to medicinal chemistry research groups at universities, research institutes, and pharmaceutical development laboratories. It is typically used in synthesis projects that explore new nitrogen-containing scaffolds, in student and postgraduate research on heterocyclic chemistry, and in analytical work on chiral separation methods. Because the reagent is supplied under the TCI brand, laboratories can rely on consistent, documented quality for reproducible results across repeated experiments and longer research programmes.
- Medicinal chemistry scaffold synthesis: the 2-arylpyrrolidine core appears in many bioactive molecules, so this compound is a direct starting point for preparing analogues and drug-candidate series.
- Amine derivatization reactions: the nucleophilic secondary nitrogen readily undergoes alkylation, acylation, sulfonylation, and reductive amination, which makes it convenient for generating diverse compound libraries.
- C–N cross-coupling studies: as a secondary cyclic amine it is a suitable coupling partner for building N-aryl pyrrolidine derivatives in modern catalytic amination methods.
- Chiral resolution and chiral chromatography: the stereogenic carbon bearing the phenyl group makes it a useful model substrate for enantiomer separation and for developing chiral analytical methods.
- Organocatalyst and ligand development: pyrrolidine frameworks are widely used in organocatalysis, and the phenyl-substituted ring provides a practical base for designing new catalysts and ligands.
| Brand | TCI (product code P2907) |
|---|---|
| CAS number | 1006-64-0 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI pack sizes; please check the product page or contact our team for current options |
| Physical form | refer to the TCI product label and Certificate of Analysis |
| Storage | follow the storage conditions stated on the TCI label and Safety Data Sheet |
Store 2-Phenylpyrrolidine in its original, tightly closed container, under the conditions given on the TCI label and Safety Data Sheet. Keep it in a cool, dry, well-ventilated area, away from heat, direct sunlight, strong oxidizing agents, and acids. Amines can react with air moisture and carbon dioxide, so reseal the container promptly after each use, and use an inert atmosphere where appropriate. Handle the compound in a fume hood while wearing gloves, safety glasses, and a lab coat. Avoid contact with skin and eyes and avoid inhaling vapours. Read the Safety Data Sheet before use, and dispose of waste according to local regulations.
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