Pemetrexed Disodium Hemipentahydrate TCI P3263

Chemical Identity

CAS No.: 357166-30-4
Purity: >97.0%(HPLC)(T)

Rp 1.272.600,00

~~Rp 905.100,00~~ Rp 1.272.600,00

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Berat 200mg 1g

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Pemetrexed Disodium Hemipentahydrate from TCI (product code P3263) is the hydrated disodium salt form of pemetrexed, an antifolate compound widely studied in oncology research. Pemetrexed inhibits several folate-dependent enzymes, including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, and so disrupts nucleotide synthesis. This product is a pharmaceutical research reagent for laboratory experiments only. It is not intended for clinical use in humans or animals, and it should be handled as a research chemical in controlled laboratory settings.

Researchers choose pemetrexed because it acts on several targets in the folate metabolic pathway. This makes it a useful reference compound for studying purine and pyrimidine synthesis. Disodium salt forms generally dissolve in water more easily than the free acid form, so they are more practical for preparing stock solutions in aqueous media. The defined hydrate structure also supports accurate concentration calculations, provided the molecular weight of the hydrate is used when weighing. The compound can also serve as a comparison standard during analytical method development, where a well-characterized reference material is needed.

In Indonesia, this reagent is relevant to pharmacology, biochemistry, and cancer biology laboratories at universities, research institutes, and pharmaceutical development facilities. Teams working on antifolate mechanisms, enzyme inhibition studies, or the development of chromatographic methods for related compounds can use it as a consistent reference material. Sourcing a recognized brand such as TCI through a local supplier like AMI Scientific helps Indonesian laboratories keep their reagent supply reliable for ongoing experimental programs and repeatable research workflows.

Related TCI products

Folate metabolism research: Pemetrexed inhibits several folate-dependent enzymes, which makes it a suitable tool for probing how disruption of folate pathways affects cellular nucleotide supply.
Enzyme inhibition studies: Its known activity against thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase supports comparative assays of these enzymes in controlled experiments.
Purine and pyrimidine synthesis studies: Because it interferes with nucleotide synthesis, researchers can use it as a reference compound when studying how these biosynthetic pathways respond to inhibition.
Oncology-focused in vitro research: Pemetrexed is a well-known antifolate in cancer research, so it is a relevant benchmark compound for experimental studies of antiproliferative mechanisms in laboratory models.
Analytical method development: The defined hydrated disodium salt form makes it useful as a comparison standard when developing and validating analytical methods for pemetrexed and related compounds.

Brand	TCI (product code P3263)
CAS number	357166-30-4
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes	Available in the pack sizes offered by TCI; please confirm the current options with AMI Scientific
Physical form	—
Storage	Follow the storage conditions stated on the TCI product label and Safety Data Sheet

Chemical form: Disodium salt, hemipentahydrate

Store Pemetrexed Disodium Hemipentahydrate in its original, tightly closed container as specified on the TCI label and Safety Data Sheet. Keep it in a cool, dry place away from moisture and direct light. Because the compound is a defined hydrate, avoid long exposure to open air so its hydration state and weighing accuracy stay consistent. Handle it only in a laboratory setting, wearing suitable personal protective equipment such as gloves, a lab coat, and safety glasses. Avoid creating dust or inhaling the powder, and work in a fume hood or ventilated area when weighing. Label prepared stock solutions clearly with the concentration and preparation date. Dispose of waste according to institutional and local regulations. This product is for experimental research use only and must not be used for diagnostic, therapeutic, or clinical purposes.

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