Combretastatin A4 Phosphate Disodium Salt TCI C3009

Name: TCI C3009 168555-66-6 Combretastatin A4 Phosphate Disodium Salt
Brand: TCI
SKU: TCI2510C300917931
Price: 4900350.0 IDR
Availability: InStock

Rp 4.900.350,00

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Berat 20mg

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Description

TCI C3009 Combretastatin A4 Phosphate Disodium Salt is a research reagent supplied as the disodium phosphate salt of combretastatin A4, a stilbenoid compound widely studied as a tumor vascular disrupting agent and an inhibitor of tubulin polymerization. In the laboratory, this material serves as a model molecule for examining microtubule dynamics, antiangiogenesis mechanisms, and the behavior of prodrug compounds that are activated enzymatically. Because it is classified as a research reagent, the product is intended exclusively for scientific experimentation in controlled environments, and is not for diagnostic or therapeutic use in humans or animals.

The characteristic that makes this compound a frequent choice is its disodium phosphate salt form. Modification with the phosphate group improves solubility in aqueous media compared with the free phenolic form, so researchers can more easily prepare stock solutions for cell culture assays without depending entirely on organic solvents such as DMSO. This prodrug property is also conceptually attractive: removal of the phosphate group by phosphatases yields the active form, which is why the compound is often used as a concrete teaching and demonstration example of enzymatically activated prodrug design. The combination of improved aqueous handling and a well-documented mechanism of action makes the material practical for routine bench work as well as for method development.

In Indonesian laboratories, this reagent is typically used in university research groups, pharmaceutical development units, and drug discovery laboratories working on drug delivery systems (DDS). It commonly supports cell culture based screening, mechanistic studies of microtubule-targeting compounds, and comparative work on prodrug activation. Work is normally carried out in laboratories equipped with fume hoods, biosafety cabinets, and cold storage, with material handled according to institutional research procedures and the supplier's safety data sheet.

Laboratory Applications

Tubulin polymerization studies: the compound is a well-characterized inhibitor of tubulin polymerization, making it a dependable reference material when researchers need a known-active molecule for in vitro assays.
Microtubule dynamics research: because its mechanism targets the microtubule system, the reagent is suitable as a model molecule for observing how cytoskeletal assembly and disassembly respond to chemical perturbation.
Antiangiogenesis and vascular disruption studies: as a compound widely studied for tumor vascular disrupting activity, it supports mechanistic investigation of how vascular structures respond in controlled experimental systems.
Prodrug activation research: the phosphate group is removed by phosphatases to release the active form, so the material serves as a practical experimental example of enzymatically activated prodrug behavior.
Drug delivery systems (DDS) development: improved aqueous solubility relative to the free phenolic form makes the salt convenient for formulation and delivery experiments that require preparation of aqueous stock solutions.

Specifications

Brand: TCI
CAS Number: 168555-66-6
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Product code: C3009
Pack sizes: available in the pack sizes listed by the manufacturer for this catalog item
Storage: store according to the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store the reagent in its original tightly closed container, protected from moisture and direct light, and follow the storage temperature stated on the manufacturer's label and safety data sheet. Amber glass vials or the supplied primary container are appropriate; transfer only what is needed and reseal promptly to limit exposure to humid air. Prepared aqueous stock solutions should be labeled with contents and preparation date and kept in clearly identified containers. Handle the material as a research chemical of unknown toxicological profile: work in a fume hood or biosafety cabinet where appropriate, wear a laboratory coat, nitrile gloves, and eye protection, avoid inhalation of dust and skin contact, and dispose of residues and contaminated consumables through the institution's chemical waste procedures. Keep the safety data sheet accessible to all users.