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Description
TCI C2236 Cyclophosphamide Monohydrate is an oxazaphosphorine compound supplied in its monohydrate form, widely recognised as an alkylating agent and used as a research reagent in pharmaceutical development and in the study of drug delivery systems. The compound is a classic prodrug: the molecule only becomes active after undergoing metabolic transformation, and it is precisely this property that makes it such a valuable model in the laboratory. Researchers use it to study prodrug activation, the mechanisms of DNA damage caused by alkylating agents, and the behaviour of the active species once it has been formulated into a carrier system.
The properties that lead researchers to select this material begin with how thoroughly it has been documented in the scientific literature, which means experimental results can be compared against a large body of earlier references rather than interpreted in isolation. The monohydrate form yields a crystalline solid that is easier to handle and to weigh consistently than the more sensitive anhydrous form, an advantage in any workflow that depends on reproducible sample preparation. Its solubility in water simplifies the preparation of test solutions, while its prodrug character makes the compound a standard comparator in formulation research, particularly when investigators want to assess whether a given carrier system successfully alters the behaviour of the parent molecule.
In Indonesian laboratories this reagent is typically found in pharmaceutical faculties, in pharmacology and biomedical research groups, and in drug delivery laboratories developing carrier systems. It supports postgraduate research projects, method development work, and comparative formulation studies where a well characterised prodrug is required as a reference point. Because its behaviour is already established in the literature, it is frequently chosen for teaching-linked research and for laboratories building experimental protocols that need to be defensible against published data.
Laboratory Applications
Prodrug activation studies — the compound only becomes active after metabolic transformation, making it a reliable model for tracing how an inactive molecule is converted into its working form.
Alkylating agent mechanism research — it is used to investigate how alkylating agents cause DNA damage, a mechanism that is extensively described in the existing scientific literature.
Drug delivery system development — researchers formulate it into carrier systems to observe how the active species behaves once it has been incorporated into a delivery vehicle.
Formulation comparison work — its prodrug character makes it a standard comparator for assessing whether a carrier system successfully changes the behaviour of the parent compound.
Aqueous test solution preparation — its solubility in water allows straightforward preparation of test solutions, supporting experimental designs that require consistent, easily reproduced sample handling.
Specifications
Brand: TCI
CAS number: 6055-19-2
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Pack sizes: available in standard laboratory pack sizes; please confirm the currently listed options when ordering
Physical form: crystalline solid, supplied as the monohydrate
Storage: store according to the manufacturer's instructions on the product label and safety data sheet
Handling and Storage
Store the container closed in a cool, dry place away from direct sunlight, moisture, and incompatible materials, following the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the material in its original tightly sealed container, or in a clean, chemically compatible and clearly labelled vessel if it is subdivided. Handle the solid in a well ventilated area or fume hood, and wear appropriate personal protective equipment including gloves, safety goggles, and a laboratory coat. Because this is a cytotoxic research reagent, avoid inhalation of dust and any contact with skin or eyes, minimise the generation of airborne particles during weighing, and restrict handling to trained personnel. Consult the safety data sheet before use, and dispose of the material and any contaminated consumables through approved chemical waste channels in accordance with institutional and local regulations.
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