Trifluoromethanesulfonyl Chloride TCI T1027

Chemical Identity

CAS No.: 421-83-0
PubChem: CID 79000·SID 87576831
Formula: CClF3O2S
Molecular weight: 168.52 g/mol
Purity: >98.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: trifluoromethanesulfonyl chloride
SMILES: C(F)(F)(F)S(=O)(=O)Cl
InChIKey: GRGCWBWNLSTIEN-UHFFFAOYSA-N

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Berat 5g 25g

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Trifluoromethanesulfonyl Chloride from TCI, catalog code T1027, is commonly known as triflyl chloride (CF₃SO₂Cl). It is a highly reactive sulfonyl halide reagent that carries the trifluoromethanesulfonyl group. In the synthesis laboratory it serves two roles. First, it is used to install the triflyl group onto amines and other nucleophiles. Second, it acts as a source of the trifluoromethyl radical (CF₃•) in photoredox and radical reactions. It is also used in certain chlorination reactions, which makes it a versatile building block for fluorine chemistry.

The triflyl group is strongly electron-withdrawing, and this is the main reason chemists choose the reagent. That property makes triflamides acidic and stable, while triflate derivatives become excellent leaving groups. In modern radical chemistry, triflyl chloride readily releases SO₂ and generates the CF₃ radical. This gives chemists a practical way to introduce the trifluoromethyl group into aromatic compounds and alkenes. The trifluoromethyl group is very important in drug design and agrochemistry, so a dependable source of it has clear value in research programs.

In Indonesian laboratories, medicinal chemistry, organic synthesis and photoredox catalysis research groups can use this reagent to develop fluorinated compounds. The 5 g pack suits method testing and small-scale route scouting, while the 25 g pack suits groups that run reactions more regularly. Because the reagent is reactive, it is best used by trained staff who work with air- and moisture-sensitive materials and have suitable fume hood facilities.

TCI brochures (PDF)

Sulfonylation Reagents 2023-01-20 · p. 2
Halogenation Reagents 2026-04-03 · p. 5
Condensing Agents 2025-11-18 · p. 8
Protecting Agents 2025-03-25 · p. 11

Related TCI products

Triflylation of amines: the reagent attaches the trifluoromethanesulfonyl group to amines, giving triflamides that are acidic and stable thanks to the strongly electron-withdrawing triflyl group.
Trifluoromethylation of aromatic compounds: under radical conditions the reagent releases SO₂ and forms CF₃ radicals, offering a practical way to introduce a trifluoromethyl group onto aromatic rings.
Photoredox catalysis research: as a source of CF₃• in photoredox reactions, it lets research groups study radical trifluoromethylation of alkenes and other substrates under light-driven conditions.
Medicinal chemistry programs: the trifluoromethyl group is important in drug design, so this reagent helps chemists prepare fluorinated analogues of lead compounds for structure-activity studies.
Selected chlorination reactions: its reactivity as a sulfonyl chloride allows it to be used in certain chlorination steps, giving synthetic chemists another option when planning a route.

Brand	TCI
CAS number	421-83-0
Molecular formula	—
Purity	—
Category	Chemistry > Synthetic Reagents > Coupling [Synthetic Reagents]
Pack sizes	5 g and 25 g
Physical form	—
Storage	keep tightly closed and protected from moisture; follow the storage guidance on the supplier label and safety data sheet

Catalog code: T1027

Store the reagent in its original tightly closed container, in a cool, dry and well-ventilated place away from moisture, since sulfonyl halides are generally sensitive to water. Follow the storage conditions printed on the label and in the safety data sheet. Keep it away from incompatible materials such as strong bases and nucleophiles. Handle it only inside a fume hood, wearing chemical-resistant gloves, safety goggles and a laboratory coat. Use dry glassware and, where the procedure requires, an inert atmosphere. Avoid inhaling vapors and avoid contact with skin and eyes. Dispose of waste according to institutional and local regulations, and read the safety data sheet before first use.

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