Difluoromethyl Trifluoromethanesulfonate (CAS 1885-46-7) is a high-quality chemical from TCI, supplied as GC Grade / for Synthesis.
Application: Synthesis reagent for a wide range of organic chemistry transformations in laboratory and industrial settings.
Specifications:
- Molecular formula: C2HF5O3S
- CAS number: 1885-46-7
- Purity: >98.0%(GC)
- TCI product code: T4382
Synonyms: Difluoromethyl Triflate; Trifluoromethanesulfonic Acid Difluoromethyl Ester
Available from AMI Scientific, the authorised TCI distributor in Indonesia. Contact us for pricing and stock availability — we ship throughout Indonesia.
Advantages (TCI brochure)
- Realizes efficient and selective introduction of difluoromethyl (CHF2) groups into hydroxy groups in phenols.
- Enables reactions to proceed within minutes at room temperature due to its high reactivity.
- Has exceptional functional group tolerance with broad applicability to complex molecular structures.
- Allows one-pot incorporation of difluoromethoxy groups from arylboronic acids, aryl halides, and arenes.
TCI brochures (PDF)
- Efficient, Easy-to-Handle, and Environmentally Benign Difluoromethylating Agent 2026-04-30 · p. 1
- Difluoromethylation Reagents, Difluoromethylenation Reagents 2026-05-18 · p. 1
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 8
Related TCI products
- TCI E1191 141573-95-7 Ethyl 3-(Difluoromethyl)-1-methylpyrazole-4-carboxylate
- TCI D4949 176969-34-9 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid
- TCI D4763 705-09-9 2-(Difluoromethyl)benzimidazole
- TCI T4037 2648079-79-0 5-(Trifluoromethyl)-5H-thianthren-5-ium Trifluoromethanesulfonate
- TCI T1604 6226-25-1 2,2,2-Trifluoroethyl Trifluoromethanesulfonate
- TCI H1276 156241-41-7 1,1,1,3,3,3-Hexafluoroisopropyl Trifluoromethanesulfonate
From the TCI brochure
- Synthesis of difluoromethyl ethers as an alternative to HCF2Cl
- Introduction of CHF2 groups into hydroxy groups in phenols
- One-pot incorporation of difluoromethoxy groups from arylboronic acids, aryl halides, and arenes
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Data from the TCI brochure
| Waktu reaksi | 2 min. (r.t.) |
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Source: TCI brochure RR228 (2026-04-30)
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References cited in the TCI brochure
- Patrick S. Fier. Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate Angewandte Chemie International Edition, 2013. doi:10.1002/anie.201209250
- Gregory Landelle. Tri- and difluoromethoxylated N-based heterocycles − Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid Journal of Fluorine Chemistry, 2017. doi:10.1016/j.jfluchem.2017.08.006

