Collection: Fluorination Reagents [Synthetic Reagents]

Fluorination Reagents [Synthetic Reagents] — a collection of synthesis reagents for introducing fluorine atoms as well as fluorinated groups such as difluoromethyl, trifluoromethyl, and trifluoromethylthio into organic molecular frameworks. The scope covers various types of electrophilic and nucleophilic fluorination reagents that replace the direct use of elemental fluorine gas.

Fluorination Reagents are widely used by synthetic and medicinal organic chemists to incorporate fluorine groups at aromatic, aliphatic, or specific functional group positions to modify the electronic properties and lipophilicity of target compounds. Reagents such as sulfur trifluoride derivatives, trifluoromethanesulfinate salts, or trifluoroiodomethane compounds are used in radical trifluoromethylation reactions, nucleophilic substitution, and deoxyfluorination of hydroxyl and carbonyl groups. This group also supports research and development of active pharmaceutical ingredients and agrochemicals that require targeted fluorine modification.

Examples of products in this collection: TCI Z0028 39971-65-8 Zinc(II) Trifluoromethanesulfinate, TCI B6231 202289-38-1 Bis(2-methoxyethyl)aminosulfur Trifluoride (ca. 50% in Tetrahydrofuran), TCI U0075 355-38-4 Undecafluorohexanoyl Fluoride, TCI C0991 1895-39-2 Sodium Chlorodifluoroacetate, TCI T4424 2314-97-8 Trifluoroiodomethane (ca 10% in Acetonitrile, ca 04mol/L), TCI C1159 3872-23-9 Copper(I) Trifluoromethanethiolate, TCI T4423 2314-97-8 Trifluoroiodomethane (ca. 10% in N,N-Dimethylformamide, ca. 0.5mol/L), TCI C1458 383-62-0 Ethyl Chlorodifluoroacetate.

Selecting a fluorination reagent requires attention to its physical form (solid, solution in a specific solvent, or dissolved gas with a stated molar concentration), purity level, and storage stability, which affect reactivity during use. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Organic Synthesis Reagents, often used together in one laboratory workflow:

• C-C Bond Formation [Synthetic Reagents]
• C-X(Non-Halogen) Bond Formation [Synthetic Reagents]
• Protection, Deprotection, Derivatization
• Acids, Bases [Synthetic Reagents]
• Chelation/Complexation Compounds
• Phase Transfer Catalysts

This collection is further divided into 5 more specific groups:

• Fluorination Reagents (Other) [Synthetic Reagents]
• Fluorination [Synthetic Reagents]
• Trifluoromethylation [Synthetic Reagents]
• Difluoromethylation [Synthetic Reagents]
• Trifluoromethylthiolation [Synthetic Reagents]

Back to Organic Synthesis Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.