Collection: Hydrogenation [Asymmetric Synthesis]

Hydrogenation [Asymmetric Synthesis] — contains chiral bisphosphine ligands and their derived metal complexes—including the DENEB framework, quinoxaline, and ruthenium-BINAP complexes—specifically designed to activate molecular hydrogen enantioselectively. The arrangement of phosphine groups around the chiral center directs the orientation of the prochiral substrate so that the hydrogenation product forms with high enantiomeric excess.

Hydrogenation in this Asymmetric Synthesis category is used by synthetic chemists to reduce prochiral double bonds—such as those in ketones, imines, or substituted alkenes—into new stereogenic centers with the help of transition metals such as ruthenium or palladium. Ligands such as Ts-DENEB and quinoxaline bisphosphine derivatives are widely applied in the synthesis of pharmaceutical intermediates and complex chiral molecules that require high-precision stereochemical control in research laboratories and process development at scale.

Example products in this collection: TCI T3078 1333981-84-2 (R,R)-Ts-DENEB(regR), TCI B6674 217648-63-0 [(2R,4R)-Pentane-2,4-diyl]bis[bis(3,5-dimethylphenyl)phosphane], TCI T3077 1384974-37-1 (S,S)-Ts-DENEB(regR), TCI D2774 145964-33-6 (R)-(+)-2-Diphenylphosphino-2'-methoxy-1,1'-binaphthyl, TCI B5302 1107608-80-9 (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxaline, TCI D6241 96183-46-9 (2R,4R)-2,4-Pentanediylbis(diphenylphosphine), TCI B5301 866081-62-1 (R,R)-(-)-2,3-Bis(tert-butylmethylphosphino)quinoxaline, TCI N1016 199541-17-8 [NH2Me2][(RuCl((S)-binap))2(mu-Cl)3].

Pay attention to the chiral configuration of the ligand (R,R or S,S) that matches the configuration of the target product, as well as the compatibility of the ligand with the precatalyst metal planned for the asymmetric hydrogenation reaction. All products are genuine products of Tokyo Chemical Industry (TCI) Japan, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Chiral Building Blocks, often used together in a single laboratory workflow:

• Chiral Non-Heterocyclic Building Blocks
• Chiral Heterocyclic Building Blocks
• Privileged Ligands and Complexes [Asymmetric Synthesis]

Back to Chiral Building Blocks. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for availability checks and lead times directly from Japan.