Phosgene Derivatives [Coupling Reagents] — a collection of chlorinated or activated carbonyl and thiocarbonyl compounds as easier-to-handle phosgene derivatives, used to form carbamate, urea, or thiocarbonyl bonds in organic synthesis. Active carbonate derivatives such as bis(pentafluorophenyl) carbonate and di(N-succinimidyl) carbonate provide reactive leaving groups toward amine or alcohol nucleophiles.
Triphosgene is commonly used as a solid substitute for phosgene in the synthesis of isocyanates, acid chlorides, and carbamates, while Thiophosgene is used by synthesis researchers to form isothiocyanate and thiocarbonyl groups on target molecules. Di(N-succinimidyl) Carbonate and Bis(4-nitrophenyl) Carbonate are commonly used in peptide chemistry and bioconjugation to activate hydroxyl groups into reactive carbonates before coupling with amines.
Product examples in this collection: TCI T1906 96989-50-3 O,O'-Di-2-pyridyl Thiocarbonate, TCI C1407 1659-31-0 Di-2-pyridyl Carbonate, TCI T1467 32315-10-9 Triphosgene, TCI C1481 5070-13-3 Bis(4-nitrophenyl) Carbonate, TCI T1320 463-71-8 Thiophosgene, TCI D1662 74124-79-1 Di(N-succinimidyl) Carbonate, TCI B3604 59483-84-0 Bis(pentafluorophenyl) Carbonate.
Pay attention to the reactivity of leaving groups, such as pentafluorophenoxy, succinimidyloxy, or nitrophenoxy, according to the target nucleophile, as well as the purity and physical form of the crystalline solids for consistent coupling results. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other parallel categories under Coupling [Synthetic Reagents], often used together in a single laboratory workflow:
Back to Coupling [Synthetic Reagents]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.
