Collection: Peptide Coupling Agents

Peptide Coupling Agents — gathers carboxylic acid activating reagents—from uronium and phosphonium salts, carbonyldiimidazole derivatives, to chloroformates—used to form amide bonds in peptide synthesis. These compounds activate carboxylic acids so they react efficiently with amine groups without excessive epimerization.

Peptide Coupling Agents are used by peptide synthesis and organic chemistry researchers to form amide bonds between carboxylic acids and amines in both solid-phase and solution-phase synthesis. Reagents such as uronium derivatives (HATU, TATU) and carbonyldiimidazole are commonly used in peptide preparation for biomolecule research, while nitrophenyl chloroformates are used to protect functional groups during multi-step synthesis stages.

Example products in this collection: TCI T2929 265651-18-1 N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium Hexafluorophosphate, TCI C0119 530-62-1 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis], TCI T2821 212333-72-7 N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate, TCI C1077 4457-32-3 4-Nitrobenzyl Chloroformate, TCI T2224 105832-38-0 N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium Tetrafluoroborate, TCI C1379 135540-11-3 1-(Chloro-1-pyrrolidinylmethylene)pyrrolidinium Hexafluorophosphate, TCI B4805 105379-24-6 O-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium Hexafluorophosphate, TCI C1400 7693-46-1 4-Nitrophenyl Chloroformate.

Choose reagents based on their leaving group, the risk of epimerization of chiral amino acids, and compatibility with the solvents and protecting group strategy used in the peptide synthesis protocol. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Coupling [Synthetic Reagents], often used together in one laboratory workflow:

• Active Esters, Additives [Coupling Reagents]
• Phosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]
• Coupling Reagents (Other)
• Triflate Formation [Coupling Reagents]
• Carbodiimides [Coupling Reagents]
• Phosgene Derivatives [Coupling Reagents]

This collection is further divided into 1 more specific group:

• Carbonyldiimidazole Derivatives [Coupling Reagents]

Back to Coupling [Synthetic Reagents]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — to check availability and lead time directly from Japan.