Collection: Carbonyldiimidazole Derivatives [Coupling Reagents]

Carbonyldiimidazole Derivatives [Coupling Reagents] — contains carbonyldiimidazole derivatives and their analogs such as carbonylditriazole and oxalyldiimidazole, which function to activate carboxylic acid groups into reactive intermediates for forming amide or ester bonds. These reagents release imidazole or triazole as a by-product that is easy to separate.

Carbonyldiimidazole Derivatives are used by synthetic organic and peptide chemists to activate carboxylic acids before coupling with amines or alcohols, thereby forming amide, ester, carbamate, and carbonate bonds without requiring additional activators. These reagents are commonly used in peptide synthesis, prodrug preparation, and biomolecule modification in synthesis laboratories.

Example products in this collection: TCI O0200 18637-83-7 1,1'-Oxalyldiimidazole, TCI C0119 530-62-1 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis], TCI C2325 41864-22-6 1,1'-Carbonyldi(1,2,4-triazole).

Selection depends on the type of leaving group (imidazole or triazole), which affects reaction rate and coupling selectivity, as well as purity and storage conditions given their sensitivity to moisture. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories parallel under Peptide Coupling Agents, often used together in one laboratory workflow:

• Active Esters, Additives [Coupling Reagents]
• Phosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]
• Coupling Reagents (Other)
• Triflate Formation [Coupling Reagents]
• Carbodiimides [Coupling Reagents]
• Phosgene Derivatives [Coupling Reagents]

Back to Peptide Coupling Agents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — for availability checks and lead time directly from Japan.