Collection: Carbodiimides [Coupling Reagents]

Carbodiimides [Coupling Reagents] — a collection of carbodiimide reagents such as DCC, EDC, and their salt derivatives (hydrochloride, methiodide) that contain the N=C=N functional group as the reactive center for activating carboxylic acids. These reagents form the core group for amide and ester bond formation through coupling reactions.

Carbodiimides are widely used as coupling reagents in peptide synthesis, amide and ester bond formation, and conjugation of biomolecules such as proteins and nucleic acids in organic and bioorganic chemistry laboratories. EDC and its hydrochloride derivative are commonly used by bioconjugation researchers because of their water solubility, while DCC is more often used in conventional organic-phase synthesis.

Example products in this collection: TCI D5347 691-24-7 N,N'-Di-tert-butylcarbodiimide, TCI C0793 2491-17-0 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate [for Peptide Synthesis], TCI D5334 22572-40-3 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide Methiodide, TCI D0254 693-13-0 N,N'-Diisopropylcarbodiimide, TCI D4029 1892-57-5 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, TCI D0436 538-75-0 N,N'-Dicyclohexylcarbodiimide, TCI D1601 25952-53-8 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis], TCI D0437 538-75-0 N,N'-Dicyclohexylcarbodiimide (25% in Pyridine, ca. 1.2mol/L).

Pay attention to the reagent's solubility (water-soluble like EDC versus DCC, which is soluble in organic solvents), salt form, and the concentration of the available solutions, as these determine compatibility with the reaction solvent. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Coupling [Synthetic Reagents], often used together in one laboratory workflow:

• Peptide Coupling Agents
• Active Esters, Additives [Coupling Reagents]
• Phosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]
• Coupling Reagents (Other)
• Triflate Formation [Coupling Reagents]
• Phosgene Derivatives [Coupling Reagents]

Back to Coupling [Synthetic Reagents]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team, the official distributor of TCI Japan in Indonesia, to check availability and lead time directly from Japan.