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Description
N,N'-Di-tert-butylcarbodiimide (DTB-CI), also known as TCI D5347, is a widely used chemical compound in laboratory settings for activating carboxyl groups during organic synthesis. It functions as a coupling agent that facilitates the formation of esters and amides from carboxylic acids through efficient activation mechanisms. This reagent is essential in chemical laboratories for its ability to enhance reaction rates without undergoing chemical changes itself, making it a reliable catalyst in various synthetic processes. Its role is critical in the development of complex organic molecules, particularly in the field of medicinal chemistry and polymer science.
DTB-CI is valued for its chemical stability under controlled conditions, although it is highly sensitive to moisture and air. Its molecular structure, featuring two tert-butyl groups, contributes to its overall stability and reactivity. These properties make it a preferred choice for researchers needing a consistent and effective reagent for activating carboxylic acid groups. The compound’s versatility allows it to be used in a wide range of reaction conditions, making it a staple in both academic and industrial research environments.
In Indonesian laboratories, DTB-CI is commonly used in organic chemistry research, especially in the synthesis of compounds requiring carboxyl group activation. It is frequently found in academic and industrial research settings, particularly in fields such as pharmaceutical development and materials science. Its reliability and effectiveness make it a go-to reagent for chemists working on complex molecular structures.
Laboratory Applications
Organic synthesis for ester and amide formation due to its efficient carboxyl activation properties
Medicinal chemistry research to develop pharmaceutical compounds requiring functional group modification
Polymer science applications for cross-linking and modifying polymer chains through carboxyl group reactions
Industrial chemical production for large-scale synthesis of organic compounds with high purity
Academic research in chemistry departments for teaching and experimental studies on coupling reactions
Specifications
Brand: TCI
CAS number: 691-24-7
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: Available in various quantities as per supplier specifications
Physical form: Solid powder
Storage note: Store in a dry, cool, and well-ventilated area away from moisture and air
Handling and Storage
DTB-CI should be stored in a dry, cool, and well-ventilated area to prevent moisture absorption, which can degrade its effectiveness. It is recommended to use airtight containers made of glass or high-density polyethylene to minimize exposure to air and humidity. Due to its sensitivity, it should be handled in a fume hood to avoid inhalation of vapors. Always ensure proper personal protective equipment is worn when handling this compound. Avoid contact with water or moisture during storage and use to maintain its chemical integrity. Regular inspection of storage conditions is advised to ensure optimal performance in laboratory applications.
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