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Description
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride (EDC.HCl) is a chemical compound widely used as a coupling agent in peptide synthesis. It plays a crucial role in activating carboxyl groups, enabling the formation of stable ester bonds between amino acid molecules. This compound is essential in laboratory settings where the synthesis of peptides is required, particularly in biochemical and pharmaceutical research. Its ability to facilitate efficient and reliable peptide bond formation makes it a fundamental reagent in modern synthetic chemistry.
EDC.HCl is known for its high reactivity and effectiveness in promoting esterification reactions. Its chemical properties allow it to activate carboxylic acid groups, making them more susceptible to nucleophilic attack by amino groups. This makes it a preferred choice for researchers working on peptide synthesis, as it ensures consistent and reproducible results. The compound's stability under certain conditions further enhances its usability in various experimental setups, contributing to its widespread adoption in both academic and industrial laboratories.
In Indonesian laboratories, EDC.HCl is commonly used in biochemical and pharmacological research. It is a key reagent in the development of vaccines, drugs, and bioactive compounds. Its availability and reliability make it an essential tool for scientists engaged in peptide-based research. The compound’s role in enabling the synthesis of complex peptide structures supports its importance in both basic and applied research.
Laboratory Applications
Peptide Synthesis: EDC.HCl is ideal for peptide synthesis due to its ability to activate carboxyl groups, enabling efficient coupling of amino acids.
Biomedical Research: It supports the development of therapeutic peptides and bioactive compounds, making it essential for biomedical studies.
Pharmaceutical Development: EDC.HCl is used in drug discovery to create peptide-based therapeutics with specific biological activities.
Biochemical Analysis: Its role in forming stable ester bonds makes it useful in biochemical assays requiring precise molecular interactions.
Drug Target Validation: It aids in the synthesis of peptides used to study protein interactions and validate drug targets in pharmacological research.
Specifications
Brand: TCI
CAS number: 25952-53-8
Category: Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes: Available in various quantities as per standard laboratory supply
Physical form: Solid powder
Storage note: Store in a cool, dry place away from moisture and light
Handling and Storage
EDC.HCl should be stored in a cool, dry environment, away from moisture and direct light to maintain its chemical integrity. It is recommended to keep the compound in a sealed container to prevent exposure to air and humidity. Due to its reactivity, it should be handled with care, using appropriate personal protective equipment such as gloves and safety goggles. It is important to ensure that the storage area is well-ventilated to avoid any potential fumes. Avoid contact with incompatible substances, and always follow standard laboratory safety protocols when working with this compound. Proper storage and handling will help preserve its effectiveness and ensure safe usage in laboratory settings.
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