1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent for Peptides Synthesis] TCI D1601

Chemical Identity

Other names: EDC·HCl · EDAC.HCl · 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride · EDC.HCl · EDAC.HCl · EDCI.HCl
CAS No.: 25952-53-8
PubChem: CID 2723939·SID 87568083
Formula: C8H17N3.HCl
Molecular weight: 191.70 g/mol
Purity: >98.0%(T)
Storage: 0-10°C
Reference databases: ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine;hydrochloride
SMILES: CCN=C=NCCCN(C)C.Cl
InChIKey: FPQQSJJWHUJYPU-UHFFFAOYSA-N
MDL: MDL00012503

Rp 1.483.650,00

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride, better known as EDC·HCl or WSC·HCl, is a carbodiimide reagent from TCI. It works as a coupling agent in peptide synthesis and amide bond formation. The reagent activates carboxyl groups so they can react with amines to form amide bonds. In organic chemistry, biochemistry and biotechnology laboratories, EDC is one of the most versatile coupling reagents available. Its uses range from peptide synthesis to protein conjugation and the surface modification of materials.

The main advantage of EDC over classic carbodiimides such as DCC is that it dissolves in water. The urea by-product it forms is also water-soluble, so it can be removed by extraction or aqueous washing without filtering off a precipitate. Because of this, EDC can be used in aqueous media, which matters greatly when working with biomolecules such as proteins, antibodies and nucleic acids. EDC is also often combined with NHS or sulfo-NHS to form a more stable active ester. This raises coupling efficiency and reduces side reactions.

In Indonesia, EDC is widely used in university organic chemistry laboratories and biotechnology research centres. Researchers rely on it for synthesising peptides and amide compounds in student and graduate research projects. They also use it for bioconjugation work, such as attaching proteins or antibodies to carriers and surfaces. Its compatibility with aqueous systems makes it a practical everyday reagent for academic and institutional laboratories working at the boundary between synthetic chemistry and the life sciences.

Advantages (TCI brochure)

Byproducts are easily removed by partition

TCI brochures (PDF)

Condensing Agents 2025-11-18 · p. 2
Bioconjugation Reagents 2026-07-07 · p. 12
Reagents for Glyco Chemistry & Biology 5th Edition · p. 137
Amino Acids and Peptide Synthesis Reagents 2025-08-14 · p. 40

Related TCI products

Peptide synthesis: EDC activates the carboxyl group of an amino acid so it couples with the amine of the next residue, and its water-soluble urea by-product simplifies purification.
Amide bond formation: As a general coupling agent, EDC links carboxylic acids and amines under mild conditions, so it is useful in many organic synthesis routes where a clean workup is required.
Protein and antibody conjugation: Because EDC works in aqueous media, it can crosslink or label proteins and antibodies without the organic solvents that could denature these biomolecules.
EDC/NHS active ester coupling: Combined with NHS or sulfo-NHS, EDC forms a more stable active ester, which improves coupling efficiency and reduces side reactions in multistep conjugation protocols.
Surface modification of materials: EDC is used to graft amine-containing molecules onto carboxyl-functionalised surfaces, which supports biosensor, nanomaterial and immobilisation research in materials and bioengineering laboratories.

From the TCI brochure

Condensation reactions, used together with HOBt
Y. 85% (Et3N-DMF)

Brand	TCI (product code D1601)
CAS number	25952-53-8
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes	Available in the pack sizes listed on the product page
Physical form	Solid reagent (see the TCI specification sheet for details)
Storage	Keep tightly closed and protected from moisture, following the conditions on the TCI label

Store EDC·HCl in its original, tightly sealed container in a cool, dry place, protected from moisture and away from incompatible materials. Carbodiimide reagents are sensitive to moisture, so open the container only as long as needed and reseal it promptly after use. If the bottle has been kept cold, let it reach room temperature before opening so condensation does not form inside. Always follow the storage conditions on the TCI label and safety data sheet. Handle the reagent in a well-ventilated area or fume hood while wearing gloves, safety glasses and a lab coat. Avoid creating or breathing in dust, and prevent contact with skin and eyes. Dispose of waste according to institutional and local chemical waste regulations.

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