TCI C1400 4-Nitrophenyl Chloroformate (CAS 7693-46-1) is a widely used activating reagent in peptide chemistry and bioconjugation. It converts alcohols and amines into activated 4-nitrophenyl carbonates or carbamates, in which 4-nitrophenolate serves as an excellent leaving group for subsequent nucleophilic attack. This two-step approach provides controlled access to unsymmetrical carbamates, prodrug linkers, activated PEG derivatives, and immobilised ligands without handling phosgene directly. AMI Scientific offers 25 g and 250 g packs; the reagent is moisture-sensitive and performs best when stored and handled under dry conditions.
TCI brochures (PDF)
- Water-solubility Enhancing Agents Superior to PEGs 2025-04-03 · p. 2
- Condensing Agents 2025-11-18 · p. 5
Related TCI products
- TCI C1077 4457-32-3 4-Nitrobenzyl Chloroformate
- TCI T0681 658-78-6 4-Nitrophenyl Trifluoroacetate
- TCI C0178 543-27-1 Isobutyl Chloroformate
- TCI B0249 6066-82-6 N-Hydroxysuccinimide [Coupling Reagent for Peptide]
- TCI P0919 771-61-9 Pentafluorophenol
- TCI M3572 214754-50-4 2-Hydroxy-5-methoxyisoindoline-1,3-dione
From the TCI brochure
- Reacts with hydroxyl-terminated polymer in pyridine, CH2Cl2 to form an activated intermediate for coupling with amine target molecules
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- Sammet (2009). 4-Nitrophenyl Chloroformate: A Versatile Coupling Reagent. Synlett doi:10.1055/s-0029-1218291
- El Seoud et al. (2006). Kinetics of the pH‐independent hydrolyses of 4‐nitrophenyl chloroformate and 4‐nitrophenyl heptafluorobutyrate in water‐acetonitrile mixtures: consequences of solvent composition and ester hydrophobicity. Journal of Physical Organic Chemistry doi:10.1002/poc.1081
- Mikulec et al. (1996). Use ofp-nitrophenyl chloroformate chemistry to immobilize protein on orthopedic biomaterials. Journal of Biomedical Materials Research doi:10.1002/(sici)1097-4636(199610)32:2<203::aid-jbm8>3.0.co;2-x
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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4-NitrobenzylChloroformate TCI C1077
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2-Hydroxy-5-methoxyisoindoline-1,3-dione TCI M3572
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N-Hydroxysuccinimide TCI H0623
Regular price From Rp 1.220.100,00Regular priceRp 868.350,00Sale price From Rp 1.220.100,00
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