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Description
TCI C0178 Isobutyl Chloroformate, CAS 543-27-1, is a versatile chloroformate reagent commonly used to activate carboxylic acids as mixed anhydrides. This classical approach supports amide and peptide bond formation at low temperature and is also applied to esters, carbamates, and analytical derivatization. AMI Scientific offers 25 g, 100 g, and 500 g packs so laboratories can match the quantity to their working scale. The reagent is corrosive, flammable, and moisture sensitive, so use a fume hood, dry glassware, and store it tightly closed in a cool, dry, well-ventilated place.
Scientific References
Nedev et al. (1993). A convenient method for synthesis of Fmoc-amino acid p-nitroanilides based on isobutyl chloroformate as condensation agent.. Tetrahedron Lettersdoi:10.1016/s0040-4039(00)60527-0
Ahmed Soomro (2014). Gas Chromatographic Determination of Amino Acids and Polyamines in Human Skin Samples using Trifluoroacetylacetone and Isobutyl Chloroformate as Derivatizing Reagents. Journal of Chromatography & Separation Techniquesdoi:10.4172/2157-7064.1000248
NEDEV et al. (1993). ChemInform Abstract: A Convenient Method for Synthesis of Fmoc‐Amino Acid p‐Nitroanilides, e.g. (S)‐(III), Based on Isobutyl Chloroformate as Condensation Agent.. ChemInformdoi:10.1002/chin.199338293
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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