Collection: SHAPE Probes [RNA Structure Analysis]
SHAPE Probes [RNA Structure Analysis] — gathers electrophilic compounds such as acylating anhydrides and imidazolide derivatives that react selectively with the 2'-hydroxyl groups of ribose on flexible RNA nucleotides, so that their reactivity patterns can chemically map the secondary and tertiary structures of RNA strands.
SHAPE probes such as benzoyl cyanide, N-acetylimidazole, or the NAI and NMIA reagents are used by RNA molecular biology researchers for the SHAPE-MaP technique and for mapping the structures of viral genomes, riboswitches, and non-coding RNA, where acylation positions are detected through reverse transcription and sequencing. This reactivity data helps validate RNA folding models experimentally and supports studies of RNA-protein interactions.
Example products in this collection: TCI B0835 613-90-1 Benzoyl Cyanide, TCI M0743 10328-92-4 N-Methylisatoic Anhydride, TCI A0694 2466-76-4 N-Acetylimidazole, TCI M3578 73043-80-8 1M7, TCI N1245 4693-02-1 5NIA, TCI M3589 4693-01-0 1M6.
Pay attention to the hydrolysis rate and specific reactivity of each reagent toward the target RNA, the purity of the material, and water-free storage conditions so that structure mapping results remain consistent and reproducible. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other categories at the same level under RNA Structure Analysis, often used together in one laboratory workflow:
Back to RNA Structure Analysis. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.
