Collection: Trimethylsilylation [GC Derivatization Reagents]

Trimethylsilylation [GC Derivatization Reagents] — includes silane reagents that convert hydroxyl, amine, or carboxylic acid groups into trimethylsilyl (TMS) derivatives, making polar compounds more volatile and thermally stable. This silylation reaction reduces polar interactions with the stationary phase of the chromatography column.

Trimethylsilylation reagents such as BSTFA and BSA are widely used by laboratory analysts to derivatize samples before gas chromatography (GC/GC-MS), especially for metabolites, fatty acids, sugars, and other polar compounds that are difficult to vaporize in their original form. Adding TMCS catalyst to the BSTFA formulation helps accelerate silylation of sterically hindered or less reactive groups.

Product examples in this collection: TCI B3402 25561-30-2 BSTFA-TMCS (99:1) [Derivatizing Reagent for GC], TCI C0306 75-77-4 Chlorotrimethylsilane, TCI B0912 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide Kit BSTFA 1 mL * 8 / Reaction vial, capacity 2 mL * 8, TCI H0089 999-97-3 1,1,1,3,3,3-Hexamethyldisilazane, TCI B0911 10416-59-8 N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL * 8 / Reaction vial, capacity 2 mL * 8, TCI M0536 7449-74-3 N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent], TCI B0830 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide, TCI M0672 24589-78-4 N-Methyl-N-trimethylsilyltrifluoroacetamide [Trimethylsilylating Agent].

Choose based on compatibility with the target functional group (OH, NH2, COOH), whether the mixture contains TMCS catalyst, and ready-to-use reaction vial packaging for easier sample preparation. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under GC Derivatization Reagents, often used together in a single laboratory workflow:

• Alkylation (Esterification) [Synthetic Reagents]
• Esterification, Alkylation [GC Derivatization Reagents]
• Silylation (Others) [GC Derivatization Reagents]
• Chiral Derivatization for Optical Purity Determination [GC Derivatization Reagents]
• Acylation [GC Derivatization Reagents]
• GC Derivatization Reagents (Others)

Back to GC Derivatization Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — to check availability and lead time directly from Japan.