• 150993-63-8 (S)-(-)-DBD-Pro-COCl [=(S)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] - AMI Scientific
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TCI

CAS 150993-63-8

(S)-(-)-DBD-Pro-COCl [=(S)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5564

(S)-(-)-DBD-Pro-COCl [=(S)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5564

Chemical Identity

CAS No.
150993-63-8
PubChem
CID 44630074·SID 87563181
Formula
C13H15ClN4O4S
Molecular weight
358.80 g/mol
Purity
>90.0%(HPLC)
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
(2S)-1-[4-(dimethylsulfamoyl)-2,1,3-benzoxadiazol-7-yl]pyrrolidine-2-carbonyl chloride
SMILES
CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)N3CCC[C@H]3C(=O)Cl
InChIKey
ZPBKQTOHYMFDLD-VIFPVBQESA-N
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This reagent, TCI A5564 150993-63-8 (S)-(-)-DBD-Pro-COCl, is a specialized derivatization reagent used in analytical chemistry to determine the enantiomeric purity (e.e.) of optically active compounds. It serves as an HPLC labeling reagent, enabling the differentiation and identification of enantiomers through chromatographic analysis. Its role in the laboratory is critical for ensuring accurate and reliable results in the study of chiral compounds.

The key properties that make this reagent a preferred choice include its high specificity for optically active substances and its ability to produce distinct chromatographic responses for each enantiomer. This specificity allows for precise quantification and separation, making it a reliable tool in analytical workflows. Additionally, the reagent maintains stability under standard laboratory conditions, ensuring consistent performance across multiple analyses.

In Indonesian laboratories, this reagent is widely used in research and quality control processes. Its application is particularly relevant in pharmaceutical and organic chemistry fields, where the determination of enantiomeric purity is essential for ensuring product safety and efficacy. It supports compliance with international standards and contributes to the advancement of scientific research in the region.

Advantages (TCI brochure)

  • Reacts with optically active alcohols or amines to form esters or amides
  • Esters and amides stable under reversed and normal phase HPLC
  • Diastereomers separable (separation factor alpha 2-hexanol = 1.2); detection limit for alcohols sub-picomol

TCI brochures (PDF)

Related TCI products

  • Pharmaceutical Analysis: This reagent is ideal for determining the enantiomeric purity of chiral drugs, ensuring compliance with regulatory standards and enhancing drug safety.
  • Organic Chemistry Research: It supports the study of optically active compounds by enabling precise separation and identification of enantiomers during analytical experiments.
  • Quality Control in Manufacturing: It plays a key role in assessing the purity of active pharmaceutical ingredients, ensuring consistency and quality in production processes.
  • Academic and Industrial Research: Its use in both academic and industrial settings facilitates the development of new chiral compounds and the optimization of analytical methods.
  • Regulatory Compliance Testing: It is essential for laboratories that need to meet international regulatory requirements for chiral compound analysis and reporting.

From the TCI brochure

  • Optical purity determination of secondary alcohols (hexan-2-ol, nonan-2-ol)

Brand TCI
CAS number 150993-63-8
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes —
Physical form —
Storage Store in a cool, dry place away from direct light

Data from the TCI brochure

Excitation wavelength450 nm (Fluorescence detection)
Emission wavelength560 nm (Fluorescence detection)
Separation factor alpha1.2 (2-hexanol)
Mobile phasen-Hexane / AcOEt = 80 / 20 (Kaseisorb LC 60-5); CH3CN / H2O = 60 / 40 (Kaseisorb LC ODS Super) (25 C, 1 mL/min)
Reaction10 mM reagent, 2 mM alcohol, 1% pyridine (Dry benzene, 80 C, 3 h)

Source: TCI brochure A1096 (2026-03-10)

This reagent should be stored in a cool, dry environment, away from direct light and sources of heat. It is recommended to keep it in a tightly sealed container to prevent moisture absorption and contamination. Due to its chemical nature, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. Avoid exposure to incompatible substances and ensure proper ventilation in the workspace. Proper storage conditions help maintain the reagent's stability and effectiveness over time, ensuring reliable results in analytical procedures.

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