3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione (CAS 2093387-36-9) is a brominated glutarimide–isoindolinone intermediate widely used as a cereblon-binding fragment in targeted protein degradation research. The aryl bromide handle allows straightforward elaboration through Suzuki, Buchwald–Hartwig, or Sonogashira couplings when attaching linkers for PROTAC assembly. Given the pharmacological class of glutarimide derivatives, the material should be weighed in a fume hood with full personal protective equipment and stored dry, cool, and protected from light. AMI Scientific supplies it in 200 mg and 1 g pack sizes for medicinal chemistry and drug discovery laboratories.
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