TCI B6527, 4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (CAS 2093536-12-8), is a brominated thalidomide analogue developed for PROTAC research. Its glutarimide–phthalimide core is a well-established cereblon (CRBN)-binding motif, while the bromine at the 4-position provides a synthetic handle for linker attachment via cross-coupling or substitution chemistry. Researchers use it to assemble bifunctional degraders and to build systematic linker libraries for targeted protein degradation studies. This product is intended for research use only and is supplied by AMI Scientific in original TCI packaging in 1 g and 5 g sizes.
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