TCI
2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione TCI D6178
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Description
2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione is a chemical compound widely used in pharmaceutical research and drug development. This compound plays a crucial role in laboratories by enabling the study of proteolysis targeting chimera (PROTAC) mechanisms. Its complex molecular structure allows it to interact specifically with target proteins, making it a key reagent in the development of compounds that can selectively degrade unwanted proteins within the body. This compound is particularly valuable in the field of targeted protein degradation, where precision and specificity are essential for the creation of effective therapeutic agents.
The compound is known for its chemical stability and ability to interact with various proteolytic enzymes, which makes it a preferred choice for researchers. Its molecular design allows for high affinity and selectivity towards specific protein targets, which is critical in the development of drugs with minimal side effects. These properties make it an essential tool for scientists working on innovative drug discovery and pharmacological research. The compound's versatility and reliability in experimental settings contribute to its widespread use in both academic and industrial research environments.
In Indonesian laboratories, this compound is commonly used by pharmacologists and chemists to develop new drugs or improve the efficacy of existing ones. It is also employed in research related to diseases associated with the accumulation of excess proteins in the body, such as neurodegenerative disorders. Its application in these contexts highlights its importance in advancing medical science and therapeutic innovation.
Laboratory Applications
- Pharmaceutical Development: This compound is ideal for developing new drugs that target specific proteins, enabling the creation of more effective and targeted therapies.
- Drug Discovery Research: It supports the identification of novel compounds that can selectively degrade harmful proteins, enhancing the efficiency of drug discovery processes.
- Proteolysis Targeting Chimera Research: Its structure allows it to interact with specific proteins, making it a key reagent in PROTAC technology for targeted protein degradation.
- Neurodegenerative Disease Studies: It is used in research on diseases like Alzheimer’s and Parkinson’s, where protein accumulation is a key factor.
- Biochemical Analysis: Its stability and reactivity make it suitable for biochemical assays that require precise protein interaction studies.
Specifications
- Brand: TCI
- CAS number: 64567-60-8
- Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Proteolysis Targeting Chimera Research Reagents
- Pack sizes: Available in various quantities as per supplier specifications
- Physical form: Solid (as per standard chemical properties)
- Storage note: Store in a cool, dry place away from light and moisture
Handling and Storage
This compound should be stored in a cool, dry environment, away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers to prevent exposure to air and humidity, which could affect its integrity. In laboratory settings, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure safety. Due to its chemical nature, it should be stored separately from incompatible substances to avoid any potential reactions. Proper labeling and storage conditions are essential to ensure its effectiveness and safety in research applications.
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