N-Butylmaleimide TCI B6849

Description

N-Butylmaleimide (CAS 2973-09-3) is an organic chemical compound belonging to the alkyl maleimide group, manufactured by TCI for laboratory research purposes. It serves as a starting material or building block in a wide range of synthetic reactions, primarily because its maleimide group is highly reactive toward thiol (–SH) groups. This reactivity makes it a dependable reagent for Michael addition reactions, the modification of biological compounds, and the formation of controlled covalent bonds between molecules. In organic chemistry, biochemistry, and materials science laboratories, N-butylmaleimide is used to construct more complex molecules, ranging from pharmaceutical intermediates and functional monomers to biomolecule conjugates. Its position within the non-heterocyclic building block category confirms its role as a versatile and widely sought-after synthetic intermediate among researchers.

The main advantage of N-Butylmaleimide lies in the selectivity of its maleimide group toward thiol groups, allowing reactions to proceed quickly, cleanly, and with relatively easy control under ordinary laboratory conditions. Compared with other maleimide derivatives, the butyl chain contributes to the compound's overall handling characteristics, making it a practical choice for routine synthesis work. The predictable and selective reactivity of the maleimide moiety enables researchers to achieve site-specific conjugation without extensive side reactions, which is especially valuable when working with sensitive biological molecules. These properties combine to make N-Butylmaleimide a preferred reagent in laboratories that require reliable, efficient, and controllable chemistry for the assembly of complex molecular architectures.

In Indonesian research laboratories, N-Butylmaleimide is commonly used in organic synthesis programs, biochemistry studies, and materials science projects. Researchers employ it to build drug-like intermediates, functional monomers for polymer research, and biomolecule conjugates for assay development and bioconjugation experiments. Because of its clean reactivity and straightforward handling, it fits well into the workflows of academic institutions, government research centers, and industrial R&D facilities across Indonesia, where it supports both teaching laboratories and advanced research projects. Its availability as a catalog building block from TCI makes it a convenient and dependable reagent for scientists planning multi-step syntheses or developing new conjugation strategies.

Laboratory Applications

• Michael addition reactions: The maleimide group acts as an excellent Michael acceptor, allowing N-Butylmaleimide to react rapidly and selectively with thiol nucleophiles under mild laboratory conditions.
• Bioconjugation and biomolecule modification: Its thiol-selective reactivity enables controlled covalent attachment to cysteine residues in peptides and proteins, supporting the construction of labeled or functionalized biomolecule conjugates.
• Synthesis of pharmaceutical intermediates: As a non-heterocyclic building block, N-Butylmaleimide provides a convenient handle for introducing maleimide functionality into drug-like scaffolds during multi-step organic synthesis.
• Functional monomer preparation: The compound can be incorporated into polymer and materials chemistry workflows to create functional monomers for the design of reactive or crosslinkable polymeric materials.
• Controlled molecular crosslinking: Its ability to form stable, defined covalent bonds between molecules makes it a trusted reagent for experiments requiring precise, site-specific molecular assembly in the laboratory.

Specifications

• Brand: TCI (product code B6849)
• Product: N-Butylmaleimide; CAS number: 2973-09-3
• Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
• Pack sizes: not stated in the reference data; confirm current pack sizes with the supplier
• Physical form and storage: physical form not stated in the reference data; store in a cool, dry place, protected from moisture and light

Handling and Storage

N-Butylmaleimide should be stored in its original, tightly sealed container in a cool, dry place, protected from moisture, heat, and direct light to preserve its reactivity. Glass containers with secure closures are suitable, and the container should be kept away from incompatible materials and open flames. Standard laboratory precautions apply: wear appropriate personal protective equipment, including gloves, safety goggles, and a laboratory coat, and handle the compound in a well-ventilated area or fume hood. Avoid inhalation of dust or vapors, avoid skin and eye contact, and wash hands thoroughly after handling. Keep the container closed when not in use, and always follow the supplier's safety data sheet and applicable local waste disposal regulations.