TCI C0267 2-Chloropropane (CAS 75-29-6) is the secondary isomer of chloropropane and a convenient source of the isopropyl group in synthesis. It is used in isopropylation reactions, Friedel–Crafts alkylation, and the preparation of isopropyl organometallic reagents. Its secondary structure also makes it a valuable teaching example when comparing substitution and elimination pathways. Supplied in 25 mL and 500 mL packs, this highly flammable liquid must be handled in a fume hood away from all ignition sources.
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- Saheb (2013). Theoretic studies on the kinetics and mechanism of multi-channel gas-phase unimolecular reactions of 1-chloropropane and 2-chloropropane. Structural Chemistry doi:10.1007/s11224-013-0240-2
- Ermacora et al. (2014). Influence of oil composition on the formation of fatty acid esters of 2-chloropropane-1,3-diol (2-MCPD) and 3-chloropropane-1,2-diol (3-MCPD) under conditions simulating oil refining. Food Chemistry doi:10.1016/j.foodchem.2014.03.130
- Gronert (1993). Theoretical studies of elimination reactions. 3. Gas-phase reactions of fluoride ion with 2-chloropropane and 1-chloropropane. The effect of methyl substituents. Journal of the American Chemical Society doi:10.1021/ja00055a039
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