5-Chlorosalicylamide TCI C0787

Chemical Identity

Other names: 5-Chloro-2-hydroxybenzamide
CAS No.: 7120-43-6
PubChem: CID 348094·SID 87565856
Formula: C7H6ClNO2
Molecular weight: 171.58 g/mol
Purity: >98.0%(HPLC)(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 5-chloro-2-hydroxybenzamide
SMILES: C1=CC(=C(C=C1Cl)C(=O)N)O
InChIKey: NNHMQZBVJPQCAK-UHFFFAOYSA-N
MDL: MDL00007980

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5-Chlorosalicylamide from TCI (CAS 7120-43-6) is a salicylamide derivative with a chlorine atom at the 5-position of the benzene ring. The molecule has a phenolic hydroxyl group and a primary amide group next to each other in the ortho position. This arrangement is typical of the salicylate family and allows an intramolecular hydrogen bond to form. As a non-heterocyclic building block, the compound is used to prepare salicylamide and salicylanilide derivatives and heterocyclic rings such as benzoxazinones. These compound classes are widely studied in medicinal chemistry and agrochemical research.

Chemists choose this compound because its ortho hydroxyl and amide groups can work together in cyclization reactions. One example is condensation with aldehydes, ketones, or other carbonyl derivatives to form six-membered heterocyclic rings. The phenol group can also be selectively alkylated or acylated, and the amide can be dehydrated or modified further. The chlorine atom at the 5-position increases lipophilicity and changes the electronic properties of the ring. This substituent appears often in bioactive salicylate compounds, so the material is a relevant starting point for structure–activity relationship studies.

In Indonesian laboratories, 5-Chlorosalicylamide is mainly used in organic synthesis research at universities, government research institutes, and industrial R&D groups working on pharmaceutical or agrochemical candidates. Researchers use it to build small libraries of substituted salicylamides and related heterocycles for screening and comparative studies. It also suits advanced undergraduate and postgraduate teaching on cyclization chemistry, functional-group selectivity, and the effect of halogen substituents on aromatic systems. Because it comes from TCI, users get consistent material that supports reproducible work across projects.

Related TCI products

Synthesis of benzoxazinone rings: the adjacent hydroxyl and amide groups can condense with aldehydes, ketones, or carbonyl derivatives to close six-membered heterocyclic rings efficiently.
Preparation of salicylanilide and salicylamide analogues: the core scaffold allows systematic changes at the amide or phenol to produce related derivatives for medicinal chemistry studies.
Structure–activity relationship studies: the 5-chloro substituent, which is common in bioactive salicylates, gives a useful reference point for comparing the effects of lipophilicity and electronic properties.
Selective O-alkylation and O-acylation: the phenolic hydroxyl group can be functionalized selectively, so researchers can explore protecting-group strategies and build ether or ester derivatives.
Amide transformation experiments: the primary amide can be dehydrated or modified further, which makes the compound useful for studying functional-group interconversion on a halogenated aromatic ring.

Brand	TCI (product code C0787)
CAS number	7120-43-6
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	as listed in the current TCI catalog offering
Physical form	refer to the TCI product label and Certificate of Analysis
Storage	follow the storage conditions stated on the TCI label and Safety Data Sheet

Store 5-Chlorosalicylamide in its original tightly closed container in a cool, dry, well-ventilated area. Keep it away from direct sunlight, moisture, and incompatible materials such as strong oxidizing agents. If you transfer the material, use clean, dry, chemically compatible glass or suitable plastic containers with clear labels. Handle the compound in a fume hood or well-ventilated area, and wear safety glasses, gloves, and a laboratory coat. Avoid creating dust, breathing it in, or letting it touch skin or eyes. Always check the TCI Safety Data Sheet for specific hazard, first-aid, and disposal guidance, and dispose of waste according to local regulations.

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