1,3-Cyclopentanedione (CAS 3859-41-4) from TCI is a cyclic 1,3-diketone whose acidic alpha protons and strong enol character make it a highly reactive nucleophilic partner. It is a classical building block for Robinson annulation and Michael additions leading to hydrindanone and fused polycyclic frameworks. Synthetic chemists frequently employ it in steroid, terpenoid, and natural product total synthesis, as well as in heterocycle construction. AMI Scientific supplies this reagent in 1 g and 5 g pack sizes for research laboratories.
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- (1992). 2-METHYL-1,3-CYCLOPENTANEDIONE. Organic Syntheses doi:10.15227/orgsyn.070.0226
- KATRUSIAK (1990). ChemInform Abstract: Structure of 1,3‐Cyclopentanedione. ChemInform doi:10.1002/chin.199043055
- Fuchs et al. (1992). A Simple Synthesis of 1,3-Cyclopentanedione. Synthesis doi:10.1055/s-1992-26114
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