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Description
TCI C1195 3-Chloro-1-butyne, CAS 21020-24-6, is a compact propargylic halide that combines a terminal alkyne with a reactive carbon–chlorine bond. It is widely used for propargylation reactions, where nucleophiles displace the chloride to install a butynyl unit that remains available for further functionalisation. The retained terminal alkyne makes it a convenient precursor for copper-catalysed azide–alkyne cycloaddition, Sonogashira coupling, and alkyne-based cyclisations. AMI Scientific offers 1 g and 5 g packs for research laboratories, and this volatile, reactive reagent must be handled in a fume hood in accordance with the manufacturer's Safety Data Sheet.
