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Description
2-Deoxy-D-glucose (2-DG) is a chemical compound that plays a significant role in chemical biology and glycoscience. It serves as a substrate for enzymatic activity and is widely used to study carbohydrate metabolism mechanisms within cells. In laboratory settings, 2-DG is a key reagent in various research areas, including diabetes, neurodegenerative diseases, and energy metabolism studies. Its ability to mimic glucose allows it to enter cells and influence glucose metabolic pathways, making it an essential tool in biomedical experiments.
The chemical structure of 2-DG is similar to glucose, but with one oxygen atom missing, which makes it highly reactive and suitable for a variety of chemical reactions. This reactivity, combined with its stability in normal environmental conditions, ensures that it remains a reliable and versatile compound for laboratory use. Its non-spontaneous decomposition further enhances its usability over extended periods, making it a preferred choice for researchers.
In Indonesian laboratories, 2-DG is extensively used in public health, pharmacology, and biotechnology research. Its role in studying metabolic processes and its compatibility with various enzymes make it a fundamental component in biochemical investigations. Researchers across different fields rely on 2-DG to explore cellular mechanisms and develop new therapeutic approaches.
Laboratory Applications
Diabetes research utilizes 2-DG to study glucose metabolism and insulin resistance mechanisms in cellular models.
Neurodegenerative disease studies employ 2-DG to investigate metabolic changes in brain cells and mitochondrial function.
Energy metabolism research benefits from 2-DG as it allows the simulation of glucose utilization in metabolic pathways.
Pharmacological studies use 2-DG to test drug effects on glucose transporters and metabolic enzyme activity.
Biotecnological applications incorporate 2-DG to explore its potential in biofuel production and metabolic engineering.
Specifications
Brand: TCI
CAS number: 154-17-6
Category: Chemistry > Chemical Biology > Glycoscience
Pack sizes: Available in various quantities as per supplier specifications
Physical form: White crystalline powder
Storage note: Store in a cool, dry place away from light
Handling and Storage
2-DG should be stored in a cool, dry place, away from direct light to maintain its chemical integrity. It is recommended to use airtight containers to prevent moisture absorption, which could affect its stability. Due to its reactivity, it should be handled with care in a well-ventilated area. Laboratory personnel should wear appropriate personal protective equipment, such as gloves and safety goggles, when handling the compound. It is important to ensure that the storage area is secure and inaccessible to unauthorized individuals. Regular monitoring of storage conditions is advised to ensure the compound remains in optimal condition for use in research applications.
